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A Review on Rheumatoid Arthritis Interventions and Current Developments.

Nikita Khanna1, Anil Kumar1, Sandip V Pawar1

  • 1University Institute of Pharmaceutical Sciences (UIPS), Panjab University, Chandigarh, India.

Current Drug Targets
|November 27, 2020
PubMed
Summary

Rheumatoid arthritis (RA) drug development is advancing with novel immunomodulatory therapies and innovative strategies like treat-to-target. Research explores new agents, delivery systems, and bioinformatics to improve RA treatment outcomes and reduce side effects.

Keywords:
Rheumatoid arthritisautoimmune disorderbioinformaticsinflammationlifestyle managementtreat to target

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Area of Science:

  • Immunology
  • Pharmacology
  • Biotechnology

Background:

  • Rheumatoid arthritis (RA) is a chronic autoimmune disease causing joint inflammation and destruction, affecting over 1.5% of the global population.
  • Current RA treatments primarily involve immunomodulatory drugs, with a significant need for novel therapeutic strategies.
  • The development of new interventions for RA is crucial due to the disease's prevalence and impact.

Purpose of the Study:

  • To review the current landscape and challenges in rheumatoid arthritis (RA) drug development.
  • To summarize innovative therapeutic approaches and emerging strategies for RA interventions.
  • To highlight the role of bioinformatics in advancing RA research and drug discovery.

Main Methods:

  • Comprehensive review of existing literature on RA genetics, etiology, clinical symptoms, and current treatments.
  • Analysis of novel therapeutic agents, including GM-CSF inhibitors and matrix metalloproteinase inhibitors.
  • Exploration of advanced drug delivery systems such as liposomes and superparamagnetic iron oxide nanoparticles (SPIONs).

Main Results:

  • Emerging strategies like treat-to-target and window of opportunity are being investigated to optimize RA therapy.
  • Novel agents and targeted delivery systems show promise for more effective RA treatment with reduced toxicity.
  • Drug repositioning and bioinformatics-based approaches are increasingly considered for chronic inflammatory disorders like RA.

Conclusions:

  • Significant advancements are being made in RA drug development, focusing on targeted therapies and personalized medicine.
  • Innovative approaches are essential to overcome challenges in RA treatment and improve patient outcomes.
  • The integration of bioinformatics and novel drug delivery systems represents a promising future for RA intervention.