Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Megakaryocyte motility and platelet formation.

R M Leven1

  • 1Division of Biology and Medicine, Lawrence Berkeley Laboratory, University of California, Berkeley 94720.

Scanning Microscopy
|December 1, 1987
PubMed
Summary

Platelets form from megakaryocyte pseudopodia fragments. This process involves microfilament changes and microtubule elongation, influenced by specific agents like cytochalasins.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Locally delivered rhTGF-beta2 enhances bone ingrowth and bone regeneration at local and remote sites of skeletal injury.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2001
Same author

Recombinant human interleukin-11 directly promotes megakaryocytopoiesis in vitro.

Blood·1997
Same author

Effect of recombinant interleukin-6 and thrombopoietin on isolated guinea pig bone marrow megakaryocyte protein phosphorylation and proplatelet formation.

Blood cells, molecules & diseases·1997
Same author

Differential regulation of integrin-mediated proplatelet formation and megakaryocyte spreading.

Journal of cellular physiology·1995
Same author

Megakaryocyte proplatelet-like process formation in vitro is inhibited by serum prothrombin, a process which is blocked by matrix-bound glycosaminoglycans.

Experimental hematology·1993
Same author

Extracellular matrix stimulation of guinea pig megakaryocyte proplatelet formation in vitro is mediated through the vitronectin receptor.

Experimental hematology·1992

Area of Science:

  • Hematology
  • Cell Biology
  • Biochemistry

Background:

  • Platelet formation is a complex process crucial for hemostasis.
  • The cytoskeleton's role in megakaryocyte fragmentation into platelets is not fully elucidated.

Purpose of the Study:

  • To review the mechanisms of platelet formation.
  • To emphasize the role of the cytoskeleton in this process.

Main Methods:

  • Review of existing literature on platelet formation theories.
  • Analysis of experimental evidence regarding megakaryocyte pseudopodia formation.

Main Results:

  • Evidence suggests platelets originate from megakaryocyte pseudopodia fragments.
  • Thrombocytopenic plasma stimulates pseudopodia formation in vitro.
  • Vincristine inhibits, while taxol and cytochalasins alter pseudopodia formation.

Conclusions:

  • Platelet formation likely occurs via megakaryocyte pseudopodia fragmentation.
  • Normal pseudopodia formation may require microfilament disorganization and microtubule elongation.

Related Experiment Videos