Related Experiment Video

Updated: Nov 28, 2025

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug
05:57

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug

Published on: May 17, 2024

997

[Effect of hypertension on outcomes of patients with COVID-19]

H U Chengyi1,2, Xiao Lushan2, Zhu Hongbo2,3

  • 1Department of Medical Quality Management, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University
|November 27, 2020
PubMed

Insights

Hypertension significantly increases the risk of bacterial infections in COVID-19 patients. These patients exhibit higher neutrophil counts and require more antibiotic treatments, underscoring the need for caution against secondary infections.

Area of Science:

  • Infectious Diseases
  • Cardiovascular Medicine
  • Critical Care

Background:

  • Hypertension is a prevalent comorbidity associated with severe outcomes in various infections.
  • The impact of hypertension on COVID-19 patient outcomes, particularly concerning secondary infections, requires further elucidation.

Purpose of the Study:

  • To investigate the influence of hypertension on the clinical characteristics and outcomes of patients diagnosed with COVID-19.
  • To assess the association between hypertension and the incidence of bacterial infections in COVID-19 patients.

Main Methods:

  • A matched cohort study involving 442 COVID-19 patients (61 with hypertension, 381 normotensive) admitted between January 1 and March 18, 2020.
  • Patients were matched 1:1 for age and gender, excluding other comorbidities to isolate the effect of hypertension.
  • Analysis included clinical characteristics, laboratory findings, and clinical outcomes in 32 matched pairs.

Main Results:

  • COVID-19 patients with hypertension showed a higher likelihood of developing bacterial infections (P=0.002) compared to normotensive patients.
  • Hypertensive patients exhibited elevated neutrophil counts (P=0.007), neutrophil/lymphocyte ratio (P=0.045), and lactate dehydrogenase levels (P=0.035).
  • Increased prevalence of bilateral patchy opacities on chest CT (P=0.012) and higher rates of antibiotic (P=0.035) and corticosteroid (P=0.035) use were observed in the hypertension group.

Conclusions:

  • Hypertension is a significant risk factor for bacterial infections in COVID-19 patients.
  • Hypertensive COVID-19 patients demonstrate inflammatory markers indicative of higher infection risk and necessitate increased antibiotic treatment.
  • Clinical vigilance and preventive measures against bacterial infections are crucial for hypertensive individuals with COVID-19.
Abstract

Keywords:
COVID-19clinical characteristicshypertensionoutcomespneumonia

More Related Videos

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension04:37

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

498
Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat08:34

Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat

Published on: November 18, 2018

7.5K

Related Concept Videos

Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
285
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
486
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.5K
Factors affecting Blood pressure01:28

Factors affecting Blood pressure

Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
5.9K
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
487
Hypertension V: Nursing Management01:23

Hypertension V: Nursing Management

The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
197