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A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound
Published on: March 21, 2025
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Developing a coordinate-based strategy to support cognitive targeted prostate biopsies and correlative
Keiran D Clement1, Lizzy Day2, Helen Rooney1
1Department of Urology, Queen Elizabeth University Hospital, 1345 Govan Rd, Glasgow G51 4TF, UK.
Asian Journal of Andrology
|November 27, 2020
Summary
A new coordinate-based method aids cognitive targeted prostate biopsies, improving cancer detection. This approach shows cancer probability decreases from apex to base and with larger prostate volumes, warranting further study.
Area of Science:
- Urology
- Medical Imaging
- Oncology
Background:
- Magnetic resonance (MR) fusion systems lack investment, hindering targeted prostate biopsies in cancer diagnostics.
- Cognitive targeted biopsies are crucial for accurate prostate cancer detection.
Purpose of the Study:
- To develop and audit a coordinate-based method for cognitive targeted prostate biopsies.
- To assess cancer detection rates and lesion localization using a novel coordinate system.
Main Methods:
- A coordinate-based system dividing the prostate into 3D units was developed.
- The method was prospectively applied to target 106 lesions in 93 men.
- Cancer detection and lesion characteristics were audited.
Main Results:
- 42.5% of targeted lesions were cancerous, with 60.0% of these being clinically significant.
- Higher PSA density correlated with cancer presence (median 0.264 vs 0.145 ng ml⁻²).
- Cancer probability decreased from apex to base (OR: 2.62) and with increasing prostate volume (OR: 1.03).
Conclusions:
- The coordinate-based method is a feasible approach to guide cognitive targeted prostate biopsies.
- Further validation studies are recommended to confirm the efficacy of this coordinate system in diverse centers.
