Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

3.8K
Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inhaled Levodopa for the Management of OFF Episodes in Patients with Parkinson's Disease: A Network Meta-analysis.

Neurology and therapy·2026
Same author

Osteoinductive chemically crosslinked hydrogel enables hydroxyapatite formation, enhanced by release of dexamethasone, strontium, and zinc, and exhibits antimicrobial properties.

RSC advances·2026
Same author

Emerging biomimetic biopolymer-based composites: advancing accessible and sustainable neural disease models and therapeutics.

Frontiers in bioengineering and biotechnology·2026
Same author

Identification of novel potentially causative RYR1 variants in individuals with malignant hyperthermia susceptibility.

Neuromuscular disorders : NMD·2025
Same author

Correction: Early Cost-Effectiveness Analysis of Intra-articular Delivery of a PBAE-DEX Conjugate for Osteoarthritis in a UK Population.

Clinical drug investigation·2025
Same author

Early Cost-Effectiveness Analysis of Intra-articular Delivery of a PBAE-DEX Conjugate for Osteoarthritis in a UK Population.

Clinical drug investigation·2025

Related Experiment Video

Updated: Nov 28, 2025

Addressing Practical Issues in Atomic Force Microscopy-Based Micro-Indentation on Human Articular Cartilage Explants
08:06

Addressing Practical Issues in Atomic Force Microscopy-Based Micro-Indentation on Human Articular Cartilage Explants

Published on: October 28, 2022

1.2K

Rheometer enabled study of cartilage frequency-dependent properties.

Stefano Perni1, Polina Prokopovich2

  • 1School of Pharmacy and Pharmaceutical Sciences, Cardiff University, King Edward VII Avenue, Redwood BuildingCardiff, CF10 3NB, UK.

Scientific Reports
|November 27, 2020
PubMed
Summary
This summary is machine-generated.

Rheometry offers a cost-effective method to measure frequency-dependent cartilage properties. This technique accurately determines viscoelasticity and hydraulic permeability, crucial for understanding tissue mechanics in health and disease.

More Related Videos

A Friction Testing-Bioreactor Device for Study of Synovial Joint Biomechanics, Mechanobiology, and Physical Regulation
09:48

A Friction Testing-Bioreactor Device for Study of Synovial Joint Biomechanics, Mechanobiology, and Physical Regulation

Published on: June 2, 2022

3.3K
A Probing Device for Quantitatively Measuring the Mechanical Properties of Soft Tissues during Arthroscopy
06:16

A Probing Device for Quantitatively Measuring the Mechanical Properties of Soft Tissues during Arthroscopy

Published on: May 1, 2020

5.8K

Related Experiment Videos

Last Updated: Nov 28, 2025

Addressing Practical Issues in Atomic Force Microscopy-Based Micro-Indentation on Human Articular Cartilage Explants
08:06

Addressing Practical Issues in Atomic Force Microscopy-Based Micro-Indentation on Human Articular Cartilage Explants

Published on: October 28, 2022

1.2K
A Friction Testing-Bioreactor Device for Study of Synovial Joint Biomechanics, Mechanobiology, and Physical Regulation
09:48

A Friction Testing-Bioreactor Device for Study of Synovial Joint Biomechanics, Mechanobiology, and Physical Regulation

Published on: June 2, 2022

3.3K
A Probing Device for Quantitatively Measuring the Mechanical Properties of Soft Tissues during Arthroscopy
06:16

A Probing Device for Quantitatively Measuring the Mechanical Properties of Soft Tissues during Arthroscopy

Published on: May 1, 2020

5.8K

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Orthopedics

Background:

  • Cartilage mechanical properties depend on load frequency, but traditional testing is complex and costly.
  • Limited understanding of cartilage development, pathology, and tissue replacement due to simplified testing methods.
  • Existing advanced techniques require specialized training and expensive equipment, hindering widespread adoption.

Purpose of the Study:

  • To adapt a commercial rheometer for determining frequency-dependent viscoelastic properties of articular cartilage.
  • To establish a user-friendly and cost-effective experimental approach for cartilage testing.
  • To investigate the impact of frequency and load on cartilage mechanical properties.

Main Methods:

  • Frequency-sweep tests were performed on immature, mature, and trypsin-treated (osteoarthritis model) cartilage samples using a rheometer.
  • Dynamic shear moduli (G*, G', G″) were measured under various applied normal loads.
  • Hydraulic permeability (KH) was estimated from rheological data.

Main Results:

  • Cartilage moduli (G*, G', G″) increased with higher frequency and applied load.
  • Mature cartilage exhibited the highest moduli, while GAG-depleted cartilage showed the lowest.
  • Hydraulic permeability (KH) decreased with increasing load; GAG-depleted cartilage had higher permeability.

Conclusions:

  • Rheometry provides a simpler, more accessible, and cost-effective method for evaluating frequency-dependent cartilage properties.
  • The developed rheometer-based methodology accurately reflects cartilage viscoelasticity and hydraulic permeability.
  • This approach can enhance the understanding of cartilage mechanics in research and clinical settings.