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Technology of deep brain stimulation: current status and future directions
Joachim K Krauss1, Nir Lipsman2, Tipu Aziz3
1Department of Neurosurgery, Hannover Medical School, Hannover, Germany.
Nature Reviews. Neurology
|November 27, 2020
Summary
Deep brain stimulation (DBS) technology is evolving. Future advancements in electrodes, batteries, and stimulation methods promise to improve treatment for neurological disorders like Parkinson's disease.
Area of Science:
- Neurosurgery
- Biomedical Engineering
- Neurology
Background:
- Deep brain stimulation (DBS) is a neuromodulation technique used for Parkinson disease, essential tremor, and dystonia.
- It is also being investigated for major depressive disorder and Alzheimer disease.
- Current DBS systems have evolved slowly over two decades.
Purpose of the Study:
- To provide a comprehensive overview of the technical development of DBS.
- To place current DBS systems in perspective.
- To predict future technological advances and challenges in DBS.
Main Methods:
- Review of technical evolution of DBS systems.
- Analysis of engineering and imaging advances.
- Examination of improved understanding of brain disorders.
Main Results:
- Engineering and imaging advances are reshaping DBS delivery.
- Breakthroughs in electrodes, batteries, and stimulation paradigms are anticipated.
- Sensing technologies are expected to enhance efficacy and tolerability.
Conclusions:
- Understanding DBS technological evolution is crucial.
- Future DBS systems will likely feature enhanced efficacy and tolerability.
- Anticipating next technological advances and hurdles is key for the field.
