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Updated: Nov 28, 2025

IridiumIII Luminescent Probe for Detection of the Malarial Protein Biomarker Histidine Rich Protein-II
Published on: July 7, 2015
Remote functional group directed C-H activation by an Ir(iii) phenanthroline complex
Rozalie Sharon Genevieve Corea1, Scott Gronert
1Department of Chemistry, Virginia Commonwealth University, 1001 W Main Street, Richmond, VA 23284, USA.
Abstract:
The regioselectivity of the C-H activation of 1-butanol and 1-methoxybutane by an iridium(iii) phenanthroline complex was studied in the gas phase and revealed activation at gamma and delta carbons. In the ether, nearly exclusive gamma activation was observed. DFT calculations were used to explore the origin of this substrate-driven selectivity. The data show that the iridium(iii) complex is a potent and potentially highly selective remote C-H activation agent.
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ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3
ortho–para-Directing Deactivators: Halogens
Photochemical Electrocyclic Reactions: Stereochemistry
Selection Rules: Photochemical Activation
Diazonium Group Substitution: –OH and –H
Radical Reactivity: Intramolecular vs Intermolecular
meta-Directing Deactivators: –NO2, –CN, –CHO, –⁠CO2R, –COR, –CO2H