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Relevant Physicochemical Methods to Functionalize, Purify, and Characterize Surface-Decorated Lipid-Based

Léna Guyon1, Anne-Claire Groo1, Aurélie Malzert-Fréon1

  • 1CERMN, UNICAEN Université de Caen Normandie, F-14000 Caen, France.

Molecular Pharmaceutics
|November 27, 2020
PubMed
Summary

Surface functionalization of lipid-based nanocarriers (LBNCs) with targeting ligands enhances drug delivery. This review covers ligands, functionalization, purification, and characterization techniques for LBNCs in nanomedicine.

Keywords:
characterizationlipid-based nanocarrierssurface functionalizationtargeting ligands

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Area of Science:

  • Nanomedicine and Drug Delivery
  • Biomaterials Science
  • Surface Chemistry

Background:

  • Lipid-based nanocarriers (LBNCs) are crucial for targeted drug delivery.
  • Surface functionalization of LBNCs with targeting ligands improves therapeutic efficacy.
  • LBNCs can overcome physiological barriers and deliver active molecules specifically.

Purpose of the Study:

  • To review current knowledge on LBNC decoration for biomedical applications.
  • To emphasize ligands, functionalization approaches, and purification methods.
  • To describe LBNC surface characterization techniques.

Main Methods:

  • Review of literature on LBNC surface functionalization.
  • Analysis of various targeting ligands and their attachment strategies.
  • Description of experimental techniques for LBNC characterization.
  • Outline of purification methods post-ligand corona formation.

Main Results:

  • LBNC functionalization with targeting ligands is a key strategy in nanomedicine.
  • Various ligands and functionalization methods exist, each with specific advantages.
  • Effective purification and characterization are essential for successful LBNC development.
  • Advanced techniques like NMR spectroscopy and ITC show promise for characterizing ligand coronas.

Conclusions:

  • Surface functionalization significantly enhances the potential of LBNCs in targeted therapies.
  • A comprehensive understanding of functionalization, purification, and characterization is vital.
  • Future research should focus on optimizing these processes for clinical translation.