Related Experiment Video
Updated: Nov 28, 2025
Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
Published on: March 7, 2025
Tailored Helicobacter pylori eradication therapy in obese patients undergoing bariatric surgery
Oscar Laudanno1, Gabriel Ahumarán2, Pablo Gollo3
1Gastroenterología , Instituto de Investigaciones Médicas "Alfredo Lanari". Universidad de Buenos Aires, Argentina.
Objectives:
to compare the efficacy and safety of a tailored quadruple concomitant therapy based on body weight, with the same scheme but with fixed doses in obese patients undergoing bariatric surgery.
Methods:
a prospective study was performed of 104 obese patients.
Results:
the weight-based therapy group achieved significantly higher eradication rates in the intention-to-treat analysis; 86.3 % (95 % CI: 74.3-93.2) vs 66.1 % (95 % CI: 52.6-77.3), p < 0.05. Relative risk: 1.31 (95 % CI: 1.05-1.63). Discontinuations and adverse events were similar in both groups.
Conclusions:
a tailored quadruple concomitant therapy based on body weight seems to be more effective than the standard quadruple concomitant therapy in obese patients.
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