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U-shape short-range extrinsic connectivity organisation around the human central sulcus
Alexandre Pron1, Christine Deruelle1, Olivier Coulon2
1Institut de Neurosciences de La Timone, Aix-Marseille Université, CNRS, UMR 7289, Marseille, France.
Brain Structure & Function
|November 27, 2020
Summary
This study maps U-shape fiber bundles in the human brain's central sulcus using diffusion MRI. A key finding shows a link between hand-related fiber bundle positions and individuals' handedness scores.
Area of Science:
- Neuroscience
- Human Brain Anatomy
- Diffusion MRI
Background:
- The central sulcus is crucial for sensory-motor functions but its short-range structural connectivity is poorly understood.
- Estimating U-shape fiber trajectories from diffusion MRI data presents significant challenges.
Purpose of the Study:
- To investigate the spatial organization of U-shape fibers along the central sulcus.
- To define a detailed connectivity space for analyzing short-range anatomical connections.
- To identify and characterize U-shape fiber bundles and their relationship with functional scores.
Main Methods:
- Utilized high-quality diffusion MRI data from 100 right-handed subjects.
- Applied advanced pre-processing pipelines and defined a novel connectivity space.
- Employed unsupervised clustering to identify U-shape fiber bundles at the group level.
Main Results:
- Described the U-shape short-range connectivity patterns along the central sulcus at a group level.
- Identified five major U-shape fiber bundles in both brain hemispheres.
- Found a significant relationship between the position of three hand-related U-shape fiber bundles and handedness scores.
Conclusions:
- This research provides a detailed map of U-shape fiber connectivity around the central sulcus.
- The findings highlight the influence of handedness on the precise anatomical organization of specific fiber bundles related to hand function.
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