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Pediatric onco-nephrology: time to spread the word : Part I: early kidney involvement in children with malignancy

Arwa Nada1, Jennifer G Jetton2

  • 1Division of Nephrology, Department of Pediatrics, Le Bonheur Children's Hospital & Saint Jude Research Hospital, The University of Tennessee Health Science Center, TN, Memphis, USA. anada@uthsc.edu.

Pediatric Nephrology (Berlin, Germany)
|November 27, 2020
PubMed

Insights

Pediatric onco-nephrology is emerging due to novel cancer therapies like CAR-T cells, posing unique kidney challenges. This growing field addresses cancer survivors

Area of Science:

  • Pediatric Nephrology
  • Oncology
  • Cancer Therapeutics

Background:

  • Onco-nephrology is a growing subspecialty in adult practice.
  • Pediatric nephrologists increasingly manage malignancy-related kidney issues.
  • Lack of specialized expertise in pediatric onco-nephrology exists.

Purpose of the Study:

  • Highlight the growing challenges in pediatric onco-nephrology.
  • Emphasize the need for specialized expertise in managing kidney-related toxicities from novel cancer therapies.
  • Advocate for the formal recognition of pediatric onco-nephrology as a subspecialty.

Main Methods:

  • Review of current literature on cancer therapies and their nephrotoxicities.
  • Analysis of the evolving landscape of pediatric oncology treatments.
  • Discussion of the impact of new therapies like CAR-T cell therapy on kidney function.

Main Results:

  • Novel cancer therapies, including CD19-targeted chimeric antigen receptor T cell (CAR-T) therapy, present unique kidney side effects.
  • Improved cancer survival rates lead to a higher incidence of chronic kidney disease in survivors.
  • Pediatric nephrologists face increasing complexity in managing treatment-related kidney complications.

Conclusions:

  • Pediatric onco-nephrology requires dedicated expertise to address complex kidney issues in childhood cancer patients and survivors.
  • The field is expanding due to advancements in cancer treatment and improved patient outcomes.
  • Formalizing pediatric onco-nephrology as a subspecialty is crucial for optimal patient care.

Keywords:
CAR-TCancerChemotherapyChildrenContrast nephropathyKidney injuryWilms tumor

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