Related Experiment Video

Updated: Nov 28, 2025

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
06:06

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Published on: July 22, 2021

6.4K

Something Old, Something New: the ACR Gout Treatment Guideline and Its Evolution from 2012 to 2020

Rebecca E Cohen1, Michael H Pillinger1,2, Michael Toprover3,4,5

  • 1Division of Rheumatology, NYU Grossman School of Medicine, New York, NY, USA.

Current Rheumatology Reports
|November 27, 2020
PubMed

Insights

The 2020 American College of Rheumatology (ACR) gout guidelines update the 2012 recommendations, offering evidence-based strategies for managing gout flares, urate-lowering therapy, and lifestyle changes.

Area of Science:

  • Rheumatology
  • Internal Medicine

Background:

  • Gout is a prevalent inflammatory arthritis affecting 4% of US adults.
  • The American College of Rheumatology (ACR) published gout management guidelines in 2012 and updated them in 2020.

Purpose of the Study:

  • To compare the 2012 ACR gout guidelines with the 2020 ACR gout guidelines.
  • To summarize key similarities and differences between the two guideline sets.

Main Methods:

  • Review and analysis of the 2012 and 2020 ACR gout guidelines.
  • Comparison of methodological approaches (RAND vs. GRADE) and specific recommendations.

Main Results:

  • Identified similarities and key differences in recommendations for gout flare treatment, imaging, urate-lowering therapy, lifestyle, and genetic testing.
  • Discussed the evidence-based approach and rationale behind the recommendations in both guidelines.

Conclusions:

  • The 2020 ACR guidelines provide an updated, evidence-based approach to gout management.
  • Key differences exist in treatment strategies, reflecting advancements in the understanding and management of gout.
Abstract

Keywords:
AllopurinolColchicineFebuxostatGoutGuidelines

More Related Videos

Author Spotlight: Minimally Invasive Ultrasound-Guided Acupotomy in Knee Osteoarthritis Treatment04:57

Author Spotlight: Minimally Invasive Ultrasound-Guided Acupotomy in Knee Osteoarthritis Treatment

Published on: April 26, 2024

958
Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain07:19

Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain

Published on: March 24, 2023

5.6K

Related Concept Videos

Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
162
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
505
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
156
Urinary Tract Calculi III: Medical Management01:30

Urinary Tract Calculi III: Medical Management

The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
103
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
15.0K
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations01:26

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
229