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[Postcoital contraception with dienogest].

G Köhler¹, E Canzler, S Lembke

¹Klinik und Poliklinik für Gynäkologie und Geburtshilfe, Bereichs Medizin der Ernst-Moritz-Arndt-Universität Greifswald.

Zentralblatt Fur Gynakologie

|January 1, 1987

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Dienogest, a progestin, showed limited efficacy as a daily postcoital contraceptive, reducing pregnancy risk but causing menstrual disorders. It is not recommended as a sole contraceptive method.

Area of Science:

Reproductive Endocrinology
Clinical Pharmacology
Contraception Research

Background:

Postcoital contraception aims to prevent pregnancy after unprotected intercourse.
Progestins are synthetic hormones used in various contraceptive formulations.
Dienogest is a progestin with potential contraceptive applications.

Purpose of the Study:

To evaluate the efficacy and tolerance of dienogest as a postcoital contraceptive.
To determine the pregnancy rate and Pearl-index for dienogest used after coitus.

Main Methods:

A clinical trial involving 58 fertile women aged 20-45 years.
Oral administration of 2 mg dienogest immediately after each coitus.
Tracking of intercourses, cycles, and pregnancies over the study period.

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Main Results:

A Pearl-index of 55.6 was observed, with 14 pregnancies in 58 women over 302 cycles.
The observed pregnancy rate was 1.6% per intercourse, reducing expected pregnancy risk by 2.5 times.
Menstrual disorders occurred in 18.9% of cycles, indicating tolerance issues.

Conclusions:

Dienogest is not suitable as a sole postcoital contraceptive agent.
Progestins like dienogest may serve as a risk-reducing method in contraceptive emergencies.
Further research is needed to explore optimal use and safety profiles of progestins in emergency contraception.