Microbiological diagnostics of inneriotrobic infections.

Area of Science:

• Medical Microbiology
• Neonatalogy
• Infectious Diseases

Background:

• Intrauterine infections pose significant risks to fetuses and newborns.
• Accurate etiological diagnosis is crucial for effective management and prevention.

Purpose of the Study:

• To evaluate the diagnostic significance of microbiological methods for bacterial intrauterine infections.
• To assess the information content of biomaterial analysis from mothers and newborns.

Main Methods:

• Retrospective and prospective analysis of microbiological studies (2011-2019).
• Examination of biomaterials (cervical canal, placenta, amniotic fluid) from 63 cases of early neonatal mortality.
• Identification of bacterial pathogens using culture methods.

Main Results:

• Coagulase-negative staphylococci (e.g., Staphylococcus epidermidis) were most frequently isolated.
• Group B streptococci were more common in placenta and amniotic fluid than cervical samples.
• Diagnostic yield of microbiological studies for pathogen confirmation and transmission did not exceed 30%.

Conclusions:

• Current microbiological methods have limited sensitivity for diagnosing intrauterine infections, especially in newborns immediately after birth.
• Increased examination frequency, sample size, and advanced techniques like molecular genetics are recommended to improve diagnostic accuracy.