Implication of regulatory networks of long noncoding RNA/circular RNA-miRNA-mRNA in diabetic cardiovascular diseases

Area of Science:

• Biochemistry
• Genetics
• Cardiology

Background:

• Diabetic cardiovascular diseases (DCVDs) represent a significant global health challenge and economic burden, stemming from diabetes mellitus.
• Noncoding RNAs, including long noncoding RNAs (lncRNAs), circular RNAs (circRNAs), and microRNAs (miRNAs), are increasingly recognized for their roles in regulating complex biological processes.
• These noncoding RNAs, particularly lncRNAs and circRNAs, can function as competing endogenous RNAs (ceRNAs), modulating miRNA activity and subsequently impacting messenger RNA (mRNA) expression.

Purpose of the Study:

• This review aims to elucidate the mechanistic, pathological, and functional roles of lncRNA/circRNA-miRNA-mRNA networks in the development and progression of DCVDs.
• It seeks to consolidate current understanding of these intricate regulatory pathways.
• The review also highlights the potential of these networks for future therapeutic interventions and prognostic evaluations in DCVDs.

Main Methods:

• This review synthesizes existing research and literature on the involvement of lncRNA, circRNA, and miRNA in diabetic cardiovascular diseases.
• It focuses on the ceRNA hypothesis, where lncRNAs and circRNAs act as miRNA decoys or sponges.
• The analysis covers mechanistic insights, pathological contributions, and functional implications of these molecular interactions.

Main Results:

• lncRNA and circRNA molecules play critical roles in regulating gene expression within the context of DCVDs by interacting with miRNAs.
• These interactions form complex regulatory networks (lncRNA/circRNA-miRNA-mRNA axes) that significantly influence the pathophysiology of diabetic cardiovascular complications.
• Dysregulation within these networks contributes to the development and progression of DCVDs.

Conclusions:

• The lncRNA/circRNA-miRNA-mRNA regulatory networks are integral to the pathogenesis of diabetic cardiovascular diseases.
• Understanding these networks provides novel insights into the molecular mechanisms underlying DCVDs.
• Targeting these pathways holds promise for the development of innovative strategies for early detection, treatment, and prognosis of DCVDs.