Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

93
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
93
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

287
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
287
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

205
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
205
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

223
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
223
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

156
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
156
Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

155
Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
155

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cobalt Single Atoms in Hexagonal Boron Nitride Host for Efficient Electrochemical Nitrate Reduction.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Four-Week vs Six-Week Antibiotic Therapy in the Management of Nonsurgically Treated Diabetic Foot Osteomyelitis: Protocol for a Multicentric, Single-Blind Randomized Clinical Trial.

JMIR research protocols·2026
Same author

Posttraumatic Soft Tissue Defects of the Heel: Comparison of Reconstructive Options and Results.

Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India·2026
Same author

Performance analysis of a biomass gasification combined cycle power plant using rice husk and sugarcane bagasse with circular utilization of ash in green concrete.

Scientific reports·2026
Same author

Enhancing mechanical performance, durability, and environmental impact assessment of green concrete incorporating industrial and agricultural wastes.

Scientific reports·2026
Same author

Recalibration of the European Kidney Function Consortium eGFR Equation for the Indian Population.

Kidney international reports·2026

Related Experiment Video

Updated: Nov 28, 2025

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

2.2K

Proteinuria in Severe Hypothyroidism: A Prospective Study.

Vijay Singh Gondil1, Aarthi Chandrasekaran1, Ashu Rastogi2

  • 1Department of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

The Journal of Clinical Endocrinology and Metabolism
|November 27, 2020
PubMed
Summary

Thyroid hormone replacement therapy significantly improved kidney function (eGFR) and reduced protein in the urine for patients with severe hypothyroidism. This suggests that kidney function decline in hypothyroidism is reversible with treatment.

Keywords:
chronic kidney diseasehypothyroidismproteinuriathyroxine

More Related Videos

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
07:38

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

Published on: May 6, 2018

8.6K
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

3.3K

Related Experiment Videos

Last Updated: Nov 28, 2025

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

2.2K
Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
07:38

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

Published on: May 6, 2018

8.6K
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

3.3K

Area of Science:

  • Nephrology
  • Endocrinology
  • Internal Medicine

Background:

  • Hypothyroidism is linked to a reversible decline in kidney function, indicated by estimated glomerular filtration rate (eGFR).
  • While cross-sectional data show a hypothyroidism-proteinuria association, the effect of treatment on proteinuria remains unclear.
  • eGFR and proteinuria are key clinical markers for assessing kidney function.

Purpose of the Study:

  • To investigate the impact of thyroid hormone replacement therapy on eGFR and 24-hour urine protein excretion.
  • To explore the reversibility of kidney function alterations in severe primary hypothyroidism.

Main Methods:

  • Prospective, observational cohort study involving adults with severe primary hypothyroidism (TSH > 50 µIU/mL).
  • Exclusion criteria included pre-existing kidney disease, urinary tract abnormalities, diabetes mellitus, or hypertension.
  • Measurements of thyroid function, eGFR, 24-hour urine protein excretion, and biochemical parameters were taken at baseline and after 3 months of therapy.

Main Results:

  • Thyroid hormone replacement therapy led to decreased TSH and increased thyroxine levels (P < .001).
  • A significant increase in eGFR (mean difference 18.25 mL/min/1.73 m2; P < .001) and a significant decrease in 24-hour urine protein excretion (mean difference -68.39 mg/day; P = .001) were observed.
  • Serum cholesterol and low-density lipoprotein levels also significantly decreased (P < .001).

Conclusions:

  • Thyroid hormone replacement therapy improves eGFR in patients with severe primary hypothyroidism.
  • Treatment effectively reduces 24-hour urine protein excretion, indicating reversible kidney function alterations.
  • These findings highlight the importance of thyroid hormone normalization for renal health in hypothyroid patients.