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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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Neonatal red blood cell transfusion.

Andréanne Villeneuve1,2, Valérie Arsenault2,3, Jacques Lacroix2,4

  • 1Division of Neonatology, CHU Sainte-Justine, Montréal, QC, Canada.

Vox Sanguinis
|November 27, 2020
PubMed
Summary

Red blood cell transfusions are common in premature infants but linked to complications. This review examines neonatal transfusion practices and guidelines, highlighting variations in thresholds and processing methods.

Keywords:
critically ill newbornerythrocyteneonatered blood celltransfusion

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Area of Science:

  • Neonatal Medicine
  • Pediatric Hematology

Background:

  • Red blood cell transfusions are frequently required by premature infants, with up to 90% of extremely low birth weight infants needing them.
  • While life-saving, neonatal transfusions are associated with increased risks of necrotizing enterocolitis, bronchopulmonary dysplasia, retinopathy of prematurity, and potential neurodevelopmental issues.

Purpose of the Study:

  • To review current red blood cell transfusion practices in neonatal intensive care units.
  • To summarize international neonatal transfusion guidelines.
  • To highlight the significant variability in transfusion thresholds and processing for neonates.

Main Methods:

  • Literature review of current transfusion practices.
  • Analysis of published neonatal transfusion guidelines from various countries.
  • Discussion of specific neonatal transfusion considerations.

Main Results:

  • Significant variation exists in red blood cell transfusion thresholds across different neonatal intensive care units and countries.
  • Current practices and guidelines for neonatal transfusion are not standardized.
  • Key issues in red blood cell processing for neonates include storage duration, irradiation, cytomegalovirus (CMV) prevention, and patient blood management.

Conclusions:

  • There is a critical need for standardized red blood cell transfusion practices and guidelines in neonatal intensive care units.
  • Further research is required to establish optimal transfusion thresholds and management strategies for preterm infants.
  • Improving patient blood management can enhance outcomes for neonates requiring transfusion.