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Effect of sodium-glucose co-transporter 2 inhibitors on hepatic parameters: A systematic review and meta-analysis of

Mario Simental-Mendía1, Adriana Sánchez-García2, Mariana Rodríguez-Ramírez3

  • 1Department of Orthopedics and Traumatology, Hospital Universitario "Dr. José E. González", Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, NL, Mexico.

Pharmacological Research
|November 27, 2020
PubMed

Insights

Sodium-glucose cotransporter-2 (SGLT2) inhibitors significantly improve liver function by reducing key enzyme levels like ALT and AST. This meta-analysis confirms their beneficial impact on hepatic parameters, offering new insights for liver health management.

Area of Science:

  • Pharmacology
  • Hepatology
  • Clinical Medicine

Background:

  • Previous studies suggest potential benefits of sodium-glucose cotransporter-2 (SGLT2) inhibitors on hepatic function, but evidence remains limited.
  • SGLT2 inhibitors are primarily used for managing type 2 diabetes and heart failure.

Purpose of the Study:

  • To conduct a meta-analysis of randomized controlled trials (RCTs) to evaluate the effect of SGLT2 inhibitors on liver function parameters.
  • To synthesize existing evidence on how SGLT2 inhibitors impact key indicators of hepatic health.

Main Methods:

  • A comprehensive search of PubMed, Web of Science, Scopus, and Google Scholar was performed to identify relevant RCTs.
  • Meta-analysis was conducted using a random-effects model, including sensitivity analysis to ensure robustness of findings.
  • Hepatic parameters analyzed included ALT, AST, AP, GGT, bilirubin, and albumin levels.

Main Results:

  • SGLT2 inhibitors significantly reduced alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (AP), and gamma-glutamyl transferase (GGT) levels.
  • A significant increase in bilirubin levels was observed with SGLT2 inhibitor therapy.
  • No significant changes were detected in albumin levels, indicating a specific impact on liver enzyme activity rather than overall protein synthesis.

Conclusions:

  • Treatment with SGLT2 inhibitors demonstrates a beneficial effect on liver function tests.
  • The observed improvements are primarily attributed to the reduction in ALT, AST, AP, and GGT concentrations.
  • SGLT2 inhibitors represent a promising therapeutic option for improving hepatic parameters in relevant patient populations.
Keywords:
Hepatic functionLiver function testsMeta-analysisSodium-glucose co-transporter-2 inhibitors

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