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Smoking and COVID-19: What we know so far
Madhur D Shastri1, Shakti D Shukla2, Wai Chin Chong3
1School of Pharmacy and Pharmacology, University of Tasmania, Hobart, Australia.
Respiratory Medicine
|November 27, 2020
Summary
Smokers may face more severe COVID-19 symptoms. Research is ongoing to confirm if smoking increases COVID-19 incidence, requiring careful analysis of diverse patient data.
Area of Science:
- Infectious Diseases
- Epidemiology
- Public Health
Background:
- The COVID-19 pandemic highlights the link between infectious diseases, host factors, and pre-existing conditions.
- Rapid data generation on SARS-CoV-2 necessitates critical evaluation of study methodologies and findings.
- Understanding the relationship between smoking and COVID-19 is crucial for public health strategies.
Purpose of the Study:
- To review and analyze recent data on the potential association between smoking and COVID-19.
- To critically assess the emerging evidence regarding smoking status and COVID-19 severity and incidence.
- To identify gaps in current research and recommend future directions.
Main Methods:
- Systematic review and critical analysis of existing epidemiological and mechanistic studies on smoking and COVID-19.
- Comparison of methodologies and outputs from various research papers.
- Evaluation of data quality, statistical controls, and phenotyping of patients regarding smoking status.
Main Results:
- Emerging evidence suggests a potential link between a history of smoking and increased likelihood of severe COVID-19 symptoms.
- Current data on whether COVID-19 incidence is higher in smokers compared to non-smokers is contradictory and inconclusive.
- Further research is needed to establish definitive causal relationships.
Conclusions:
- While smoking is a known risk factor for lung diseases, its precise role in COVID-19 requires further investigation.
- Caution is advised in interpreting current findings due to limitations in existing studies.
- Future research should focus on diverse geographical settings, larger patient cohorts, and robust control for confounding factors.
Keywords:
Angiotensin-converting-enzyme (ACE)-IICoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)SmokingTherapeutic targetsMore Related Videos
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