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Effect of migraine attack on pupil size, accommodation and ocular aberrations
Merve Beyza Yildiz1, Elvin Yildiz1, Sevcan Balci1
1Department of Ophthalmology, Haydarpaşa Numune Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
European Journal of Ophthalmology
|November 28, 2020
Summary
Migraine attacks cause pupil size reduction and altered accommodation, suggesting subtle oculosympathetic hypofunction. Ocular higher-order aberrations (HOAs) remained unchanged during attacks.
Area of Science:
- Ophthalmology and Neuroscience
- Autonomic Nervous System Function
Background:
- Migraine is a complex neurological disorder with potential ocular manifestations.
- Understanding ocular changes during migraine attacks is crucial for diagnosis and management.
Purpose of the Study:
- To evaluate pupil size, accommodation, and ocular higher-order aberrations (HOAs) in migraine patients during attacks.
- To compare these ocular parameters between migraine attacks, interictal periods, and healthy controls.
Main Methods:
- Prospective case-control study involving 24 migraine patients and 24 healthy controls.
- Measurements included pupil size, accommodative responses (0-5D), and HOAs using a Hartmann Shack aberrometer.
- Patients were assessed during both interictal and ictal phases.
Main Results:
- Pupil size significantly decreased during migraine attacks (5.85 mm) compared to the interictal phase (6.05 mm).
- Accommodative response increased significantly during migraine attacks for stimuli between 1.5-5D.
- No significant changes in HOAs were observed; no parameters differed significantly from controls.
Conclusions:
- Findings suggest subtle oculosympathetic hypofunction during migraine attacks.
- Autonomic dysfunction during migraine appears to affect ocular accommodation.
- Ocular HOAs are not significantly altered during migraine attacks.
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