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Immunological classification of gliomas based on immunogenomic profiling
Qiushi Feng1,2,3, Lin Li1,2,3, Mengyuan Li1,2,3
1Biomedical Informatics Research Lab, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China.
Journal of Neuroinflammation
|November 28, 2020
Summary
This study classifies gliomas into three subtypes based on their immune microenvironment (TIM). Lower immune infiltration correlates with better survival, suggesting a new approach for glioma immunotherapy.
Area of Science:
- Oncology
- Immunology
- Genomics
Background:
- Gliomas exhibit significant heterogeneity within their tumor immune microenvironment (TIM).
- A comprehensive classification of gliomas based on immunogenomic profiling is currently lacking.
Purpose of the Study:
- To classify gliomas based on immunogenomic profiling.
- To investigate the relationship between immune infiltration and clinical outcomes in gliomas.
Main Methods:
- Hierarchical clustering of gliomas using enrichment levels of 28 immune cells across five datasets.
- Classification into three subtypes: immunity-high, immunity-medium, and immunity-low.
Main Results:
- Glioblastomas predominantly fall into immunity-high and immunity-medium subtypes.
- Lower-grade gliomas are found across all subtypes, with a majority in immunity-low.
- Immunity-low gliomas show better survival, indicating a negative correlation between immune infiltration and prognosis.
- Elevated immunity in gliomas is associated with increased tumor stemness, epithelial-mesenchymal transition, higher grade, and genomic instability.
- IDH mutations show a negative correlation with glioma immunity.
Conclusions:
- Identification of immune-specific glioma subtypes offers potential for targeted glioma immunotherapy.
- This classification provides a framework for understanding glioma heterogeneity and guiding treatment strategies.
Keywords:
ClusteringGlioblastomaGliomaImmunogenomic profilingImmunological classificationLower-grade gliomaTumor immune microenvironment
