Factors affecting opioid management for injured children after hospital discharge

Anna Delamerced1, Mark R Zonfrillo2, Kristina Monteiro3

  • 1Primary Care-Population Medicine Program, Alpert Medical School of Brown University, 222 Richmond St, Providence, RI, USA 02903.

Insights

Pediatric opioid prescriptions after injury often exceed children's needs. Most unused prescription opioids are stored improperly and not disposed of, posing risks. Further research is needed to address prescribing gaps and improve education.

Area of Science:

  • Pediatric Trauma Surgery
  • Pain Management
  • Public Health

Background:

  • Prescription opioid misuse is a significant national crisis.
  • Injured children frequently receive opioid prescriptions upon hospital discharge.
  • The role of these pediatric prescriptions in the broader opioid crisis remains unclear.

Purpose of the Study:

  • To investigate the utilization, storage, and disposal of opioid medications prescribed to injured children.
  • To understand parent/guardian perceptions of their child's pain management post-injury.
  • To identify potential gaps in opioid prescribing and discharge education.

Main Methods:

  • A prospective, two-step survey of parents/guardians of injured children admitted to a Level 1 Pediatric Trauma Center.
  • Surveys assessed pain duration, opioid administration, storage, disposal practices, and education.
  • Data collected via enrollment survey pre-discharge and follow-up survey 7-10 days post-discharge.

Main Results:

  • 61.4% of enrolled parents completed the follow-up survey.
  • Of those prescribed opioids, 79.1% filled the prescription, with 92.5% of those filling it.
  • Most children (75%) used opioids for less than 3 days; 83.7% of filled prescriptions had leftover doses.
  • Unused opioids were often stored in unlocked locations (e.g., bathroom cabinets) and 38.2% had no disposal plan.

Conclusions:

  • Severe pain requiring opioids typically resolves within 72 hours for injured children.
  • Prescription opioid quantities often exceed actual patient needs.
  • Insecure storage and lack of disposal plans for unused pediatric opioids highlight critical areas for intervention and education.
Abstract

Related Concept Videos

Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
621
Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
1.2K
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
692
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
117
Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.7K
Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents01:17

Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents

Diarrhea, a condition marked by frequent loose or watery bowel movements, can be triggered by multiple factors such as viral or bacterial infections, food intolerances, anxiety, medications, and digestive disorders. Symptoms may include abdominal pain, bloating, nausea, and cramping. Severe or prolonged diarrhea can lead to complications like electrolyte imbalances, malnutrition, and dehydration if left untreated.
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
478