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Assessment of Nerve Injury-Induced Mechanical Hypersensitivity in Rats Using an Orofacial Operant Pain Assay
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When orofacial pain needs a heart repair
Daniela Adamo1, Elena Calabria1, Noemi Coppola1
1Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II of Naples, Naples, Italy.
Clinical and Experimental Dental Research
|November 28, 2020
Summary
This case study reveals a novel link between chronic orofacial pain and congenital heart disease, specifically a right-to-left shunt (RLS) caused by a patent foramen ovale (PFO). Closing the PFO led to complete pain remission, suggesting PFO as a potential cause of facial pain.
Area of Science:
- Cardiology
- Neurology
- Pain Medicine
Background:
- Congenital heart disease (CHD) and chronic orofacial pain (COFP) association is undocumented.
- Prothrombotic states can increase stroke risk in patients with CHD.
Observation:
- A 48-year-old female with persistent idiopathic facial pain (PIFP) was found to have hyperhomocysteinemia and a high degree of right-to-left shunt (RLS).
- Further evaluation revealed an interatrial septum aneurysm with a patent foramen ovale (PFO).
Findings:
- Percutaneous closure of the PFO was performed to mitigate cryptogenic stroke risk.
- Complete remission of orofacial pain was achieved post-PFO closure.
Implications:
- This case suggests a potential association between RLS via PFO and COFP.
- Early detection of PFO in patients with atypical facial pain may prevent stroke and improve pain management.
- Interdisciplinary communication is crucial for diagnosing and managing complex cases involving facial pain and potential cardiac abnormalities.
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