Associations between MTHFR gene polymorphisms and the risk of intracranial hemorrhage: Evidence from a meta-analysis
Fenghui Wang1, Zhendong Xu1, Haiyan Jiao2
1Department of Neurosurgery, Pingdu People's Hospital Affiliated to Weifang Medical College, Pingdu, China.
Introduction:
Previously, a number of genetic epidemiological studies have evaluated associations between MTHFR gene polymorphisms and the risk of intracranial hemorrhage (ICH), with controversial results. Accordingly, we carried out this meta-analysis to more conclusively evaluate associations between MTHFR gene polymorphisms and the risk of ICH.
Methods:
MEDLINE, EMBASE, Wanfang, VIP, and CNKI were searched comprehensively, and thirty-one genetic association studies were finally selected to be included in this meta-analysis.
Results:
Eight literatures (963 cases and 2,244 controls) assessed relationship between MTHFR rs1801131 (A1298C) polymorphism and the risk of ICH, and thirty-one literatures (3,679 cases and 9,067 controls) assessed relationship between MTHFR rs1801133 (C677T) polymorphism and the risk of ICH. We found that AA genotype of rs1801131 polymorphism was significantly associated with a decreased risk of intraventricular hemorrhage (IH) compared with AC/CC genotypes (OR = 0.63; p = .003), AC genotype was significantly associated with an increased risk of IH compared with AA/CC genotypes (OR = 1.55; p = .005), and A allele was significantly associated with a decreased risk of IH compared with C allele (OR = 0.75; p = .02). Additionally, CC genotype of rs1801133 polymorphism was significantly associated with a decreased risk of cerebral hemorrhage (CH) compared with CT/TT genotypes (OR = 0.75; p = .04), TT genotype was significantly associated with an increased risk of CH compared with CC/CT genotypes (OR = 1.27; p = .02), and C allele was significantly associated with a decreased risk of CH compared with T allele (OR = 0.85; p = .007).
Conclusions:
This meta-analysis shows that rs1801131 polymorphism may influence the risk of IH, while rs1801133 polymorphism may influence the risk of CH.
Insights
This meta-analysis found MTHFR gene polymorphisms are linked to intracranial hemorrhage risk. Specifically, rs1801131 affects intraventricular hemorrhage risk, and rs1801133 influences cerebral hemorrhage risk.
Area of Science:
- Genetics
- Epidemiology
- Neurology
Background:
- Genetic variations in the MTHFR gene have been investigated for their association with intracranial hemorrhage (ICH) risk.
- Previous genetic epidemiological studies yielded controversial results regarding these associations.
Purpose of the Study:
- To conduct a comprehensive meta-analysis to clarify the relationship between MTHFR gene polymorphisms and the risk of intracranial hemorrhage (ICH).
- To evaluate the specific roles of MTHFR rs1801131 (A1298C) and rs1801133 (C677T) polymorphisms in ICH risk.
Main Methods:
- A systematic literature search was performed across multiple databases including MEDLINE, EMBASE, Wanfang, VIP, and CNKI.
- Thirty-one genetic association studies were identified and included in the meta-analysis, encompassing a significant number of cases and controls.
Main Results:
- The MTHFR rs1801131 (A1298C) polymorphism showed significant associations with intraventricular hemorrhage (IH) risk: AA genotype decreased risk (OR=0.63), AC genotype increased risk (OR=1.55), and A allele decreased risk (OR=0.75).
- The MTHFR rs1801133 (C677T) polymorphism was significantly associated with cerebral hemorrhage (CH) risk: CC genotype decreased risk (OR=0.75), TT genotype increased risk (OR=1.27), and C allele decreased risk (OR=0.85).
Conclusions:
- The MTHFR rs1801131 polymorphism appears to influence the risk of intraventricular hemorrhage (IH).
- The MTHFR rs1801133 polymorphism may play a role in the risk of cerebral hemorrhage (CH).
- These findings contribute to a clearer understanding of the genetic underpinnings of different types of intracranial hemorrhages.
