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Updated: Nov 28, 2025

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
Published on: September 28, 2022
Epstein-Barr virus microRNAs in the pathogenesis of human cancers
Brunno Felipe R Caetano1, Beatrice Adrianne S Jorge2, Bárbara Grasiele Müller-Coan1
1São Paulo State University (UNESP), Medical School of Botucatu Av. Prof. Mário Rubens Guimarães Montenegro, s/n. CEP 18618-687, Botucatu, SP, Brazil; São Paulo State University (UNESP), Institute of Biotechnology (IBTEC) Alameda das Tecomarias, s/n. CEP 18607-440, Botucatu, SP, Brazil.
Abstract:
The Epstein-Barr Virus (EBV) is a gamma-herpesvirus involved with a variety of human cancers, notably the endemic Burkitt lymphoma and nasopharyngeal carcinoma. In 2004, EBV was described as one the first known human oncoviruses to encode viral microRNAs (miRNAs), and these molecules were found to interact with viral and host targets. EBV miRNAs modulate biological processes that are critical for carcinogenesis, contributing to cell transformation and tumor progression of EBV-associated cancers. Herein we review and discuss EBV miRNAs as modulators of viral biology and carcinogenesis, as well as their usefulness as putative markers to monitor the onset, progression, and recurrence of cancers associated with the EBV infection.
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