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Parkinson's disease and skin
Nicki Niemann1, Andrew Billnitzer2, Joseph Jankovic2
1Muhammad Ali Parkinson Center, Department of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA.
Parkinsonism & Related Disorders
|November 28, 2020
Summary
Parkinson's disease (PD) is linked to various skin conditions. Studying these dermatologic disorders offers insights into PD mechanisms and potential new therapies.
Area of Science:
- Neurology
- Dermatology
- Pathophysiology
Background:
- Parkinson's disease (PD) frequently co-occurs with dermatologic conditions.
- Skin manifestations in PD patients can be broadly categorized into non-iatrogenic and iatrogenic types.
- Understanding these skin disorders may illuminate PD's underlying mechanisms.
Purpose of the Study:
- To review the spectrum of skin disorders associated with Parkinson's disease.
- To explore the role of skin in PD pathogenesis, diagnostics, and therapeutic development.
Main Methods:
- Comprehensive literature review of dermatologic conditions in Parkinson's disease patients.
- Analysis of iatrogenic and non-iatrogenic skin disorders related to PD treatments.
- Examination of recent research on alpha-synuclein in skin and stem cell therapies.
Main Results:
- Non-iatrogenic disorders include melanoma, seborrheic dermatitis, sweating abnormalities, bullous pemphigoid, and rosacea.
- Iatrogenic disorders arise from antiparkinsonian medications (e.g., carbidopa/levodopa, dopamine agonists) and delivery systems (e.g., deep brain stimulation).
- Skin fibroblasts are crucial for induced pluripotent stem cell research in PD.
Conclusions:
- The skin serves as a valuable model for studying Parkinson's disease pathogenesis.
- Skin-derived stem cells offer potential for novel PD therapies and diagnostics.
- Further research into skin manifestations can advance drug discovery for Parkinson's disease.
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