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Related Concept Videos

Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
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Parkinson's Disease: Overview01:15

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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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Related Experiment Video

Updated: Nov 28, 2025

Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay
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Parkinson's disease and skin.

Nicki Niemann1, Andrew Billnitzer2, Joseph Jankovic2

  • 1Muhammad Ali Parkinson Center, Department of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA.

Parkinsonism & Related Disorders
|November 28, 2020
PubMed
Summary

Parkinson's disease (PD) is linked to various skin conditions. Studying these dermatologic disorders offers insights into PD mechanisms and potential new therapies.

Keywords:
ApomorphineBiopsyBullous pemphigoidDeep brain stimulationDiagnosisLevodopaLevodopa-carbidopa intestinal gelLivedo reticularisMelanomaNodulesParkinson's diseaseRosaceaSeborrheic dermatitisSkinSweating

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The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease
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The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease
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Area of Science:

  • Neurology
  • Dermatology
  • Pathophysiology

Background:

  • Parkinson's disease (PD) frequently co-occurs with dermatologic conditions.
  • Skin manifestations in PD patients can be broadly categorized into non-iatrogenic and iatrogenic types.
  • Understanding these skin disorders may illuminate PD's underlying mechanisms.

Purpose of the Study:

  • To review the spectrum of skin disorders associated with Parkinson's disease.
  • To explore the role of skin in PD pathogenesis, diagnostics, and therapeutic development.

Main Methods:

  • Comprehensive literature review of dermatologic conditions in Parkinson's disease patients.
  • Analysis of iatrogenic and non-iatrogenic skin disorders related to PD treatments.
  • Examination of recent research on alpha-synuclein in skin and stem cell therapies.

Main Results:

  • Non-iatrogenic disorders include melanoma, seborrheic dermatitis, sweating abnormalities, bullous pemphigoid, and rosacea.
  • Iatrogenic disorders arise from antiparkinsonian medications (e.g., carbidopa/levodopa, dopamine agonists) and delivery systems (e.g., deep brain stimulation).
  • Skin fibroblasts are crucial for induced pluripotent stem cell research in PD.

Conclusions:

  • The skin serves as a valuable model for studying Parkinson's disease pathogenesis.
  • Skin-derived stem cells offer potential for novel PD therapies and diagnostics.
  • Further research into skin manifestations can advance drug discovery for Parkinson's disease.