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MicroRNA expression profiling reveals potential roles for microRNA in the liver during pigeon (Columba livia)

Xun Wang1, Peiqi Yan1, Lei Liu1

  • 1Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, P. R. of China.

Poultry Science
|November 29, 2020
PubMed

Insights

This study reveals novel microRNAs (miRNAs) in pigeon livers across development. Differentially expressed miRNAs are linked to liver growth and function, offering insights into squab development.

Area of Science:

  • * Animal Developmental Biology
  • * Molecular Biology
  • * Genomics

Background:

  • * The liver is crucial for animal metabolism, growth, and development.
  • * Limited knowledge exists regarding microRNA (miRNA) roles in pigeon liver development.
  • * Understanding miRNA expression is key to deciphering developmental processes.

Purpose of the Study:

  • * To comprehensively investigate miRNA transcriptomes in pigeon livers at various developmental stages.
  • * To identify differentially expressed miRNAs during pigeon liver development.
  • * To elucidate the functional roles of these miRNAs and their target genes in liver development.

Main Methods:

  • * Small RNA sequencing was employed to profile miRNA transcriptomes.
  • * Analysis included identifying known, conserved, and novel miRNAs.
  • * Bioinformatic tools like Short Time-series Expression Miner and network analyses were used.

Main Results:

  • * 312 known, 433 conserved, and 192 novel miRNAs were identified in pigeon livers.
  • * A set of differentially expressed miRNAs crucial for liver development and function was identified.
  • * Key target genes involved in growth regulation and signaling pathways were pinpointed.

Conclusions:

  • * This study significantly expands the known pigeon miRNA repertoire.
  • * Identified miRNAs and their targets provide novel insights into pigeon liver development mechanisms.
  • * Findings contribute to understanding the rapid development of squab through a liver-centric perspective.
Keywords:
developmentlivermiRNApigeonsmall RNA-Seq

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