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Related Experiment Video

Updated: Nov 28, 2025

Construction of Local Field Potential Microelectrodes for in vivo Recordings from Multiple Brain Structures Simultaneously

Construction of Local Field Potential Microelectrodes for in vivo Recordings from Multiple Brain Structures Simultaneously

Published on: March 14, 2022

Construction of simple, customised, brain-spanning, multi-channel, linear microelectrode arrays.

Ashik Banstola¹, Carlos Silva¹, Katharina Ulrich¹

¹Dept. Psychology, University of Otago, Dunedin, New Zealand.

Journal of Neuroscience Methods

|November 29, 2020

Summary

Researchers developed a simple, cost-effective method for creating linear micro-electrode arrays (MEAs). This new technique allows for customizable electrode spacing and length, enabling versatile applications in neuroscience research.

Keywords:

Construction Customised Multi-electrode array

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Area of Science:

Neuroscience
Bioengineering
Electrophysiology

Background:

Multichannel micro-electrode arrays (MEAs) are crucial for neural recordings but are typically complex and expensive to produce.
Existing methods for MEA construction present significant barriers in terms of cost and procedural complexity.

Purpose of the Study:

To present a novel, simple, and cost-effective method for constructing linear micro-electrode arrays (MEAs).
To enable customizable MEA designs with variable lengths and electrode spacing for diverse experimental needs.

Main Methods:

Detailed step-by-step instructions for MEA construction, including jig setup, electrode fabrication, microwire treatment, soldering, and array customization.
Surgical implantation techniques for multiple MEAs and micro-stimulation electrodes in free-moving rodents for in vivo experiments.
Testing procedures for MEA resistance and connection integrity.

Main Results:

Demonstration of multi-site local field potential recordings in awake, free-moving rodents over extended periods (months).
Examples of electrical stimulation effects on cortical and hippocampal recordings, including clear phase reversal and amplitude changes in hippocampal layers.
Successful in vivo implantation and recording using the developed MEAs.

Conclusions:

The described method offers a flexible and affordable approach to linear MEA fabrication.
The developed MEAs are suitable for prolonged in vivo recordings and electrical stimulation in rodents.
The MEA platform can be adapted for other stimulation modalities, such as optogenetic probes.