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Drug resistant Tuberculosis: A review
Jessy Lallungawi Khawbung1, Durbba Nath1, Supriyo Chakraborty1
1Department of Biotechnology, Assam University, Silchar, 788011, Assam, India.
Comparative Immunology, Microbiology and Infectious Diseases
|November 29, 2020
Summary
Tuberculosis (TB) resistance to drugs is increasing due to Mycobacterium tuberculosis evolution. This review explores molecular mechanisms driving drug resistance, leading to multi-drug resistant, extensively drug resistant, and totally drug resistant TB.
Area of Science:
- Microbiology
- Molecular Biology
- Genetics
Background:
- Tuberculosis (TB) declared a global emergency in 1993.
- Public ignorance grew despite TB curability, facilitating pathogen evolution.
- Mycobacterium tuberculosis evolved drug resistance, leading to MDR-TB and XDR-TB.
Purpose of the Study:
- To review the molecular mechanisms of Mycobacterium tuberculosis drug tolerance.
- To understand the genetic basis of resistance development.
- To elucidate pathways leading to TDR-TB.
Main Methods:
- Literature review of molecular mechanisms of drug resistance in TB.
- Analysis of genetic and pathophysiological factors in Mycobacterium tuberculosis.
- Examination of resistance pathways to anti-TB drugs.
Main Results:
- Mycobacterium tuberculosis exhibits continuous evolution of drug resistance.
- Drug resistance progresses from MDR-TB to XDR-TB and potentially TDR-TB.
- Understanding molecular mechanisms is crucial for combating TB resistance.
Conclusions:
- Molecular insights into drug tolerance are essential for TB control.
- Further research into resistance mechanisms can guide new therapeutic strategies.
- Addressing drug resistance is critical to manage the global TB burden.
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