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Updated: Nov 28, 2025
08:30
MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR qPCR
Published on: May 16, 2012
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FRMD6 has tumor suppressor functions in prostate cancer
Jakob Haldrup1,2, Siri H Strand1,2, Clara Cieza-Borrella3
1Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.
Oncogene
|November 29, 2020
Summary
FRMD6 is a novel tumor suppressor gene in prostate cancer (PC). Lower FRMD6 levels indicate higher recurrence risk and promote tumor growth, suggesting it as a prognostic biomarker and therapeutic target.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Prognostic tools for prostate cancer (PC) require improvement through understanding genes driving tumor aggressiveness.
- Aberrant gene expression is implicated in PC progression and recurrence.
Purpose of the Study:
- To identify and characterize novel genes involved in prostate cancer aggressiveness.
- To evaluate the potential of FRMD6 as a prognostic biomarker and therapeutic target in PC.
Main Methods:
- Identified FRMD6 as hypermethylated and downregulated in PC.
- Utilized cell line experiments (overexpression, CRISPR/Cas9 knockout) and mouse models (orthotropic xenografts, ROSA26 knockout).
- Performed transcriptomic, proteomic, phospho-proteomic profiling, Connectivity Map analysis, and drug repurposing.
Main Results:
- Low FRMD6 expression correlated with increased postoperative biochemical recurrence in PC patients.
- FRMD6 suppressed PC cell viability, proliferation, cell cycle, colony formation, spheroid growth, and tumor xenograft growth.
- FRMD6 deficiency activated Hippo/YAP and c-MYC signaling pathways.
- Pyroxamide emerged as a potential therapy for FRMD6-deficient PC.
- FRMD6/Pten double knockout mice showed high-grade prostatic intraepithelial neoplasia (HG-PIN) and hyperproliferation compared to Pten single knockouts.
Conclusions:
- FRMD6 functions as a tumor suppressor gene in prostate cancer.
- FRMD6 is a potential prognostic biomarker for PC recurrence.
- Targeting FRMD6 or related pathways may offer new therapeutic strategies for PC.
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