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[A means of refining the sterilization criterion]
Antibiotiki I Meditsinskaia Biotekhnologiia = Antibiotics and Medical Biotechnology
|September 1, 1987
Summary
A new sterilization criterion improves thermal sterilization efficiency for nutrient media. This updated method provides more accurate retention time calculations, closely matching experimental microbial death times.
Area of Science:
- Microbiology
- Bioprocess Engineering
- Food Science
Context:
- Traditional sterilization criteria for nutrient media may not fully account for operational variables.
- Accurate thermal sterilization is crucial for preventing microbial contamination in various applications.
Purpose:
- To introduce and validate a new sterilization criterion for thermal sterilization of nutrient media.
- To experimentally determine corrections for the sterilization criterion based on operational factors.
Summary:
- The study replaces the conventional sterilization criterion with a novel one, incorporating factors like nutrient media contamination, retention time, and microbial death kinetics.
- Calculations using the new method showed retention times significantly closer to experimental microbial death times compared to the routine procedure.
Impact:
- This research offers a more precise method for calculating thermal sterilization parameters.
- Improved accuracy in sterilization calculations can enhance process efficiency and product safety in biopharmaceutical and food industries.