Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Nov 28, 2025

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug
07:50

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug

Published on: June 4, 2021

3.0K

Treating Porcine Abscesses with Histotripsy: A Pilot Study.

Thomas J Matula1, Yak-Nam Wang1, Tatiana Khokhlova2

  • 1Applied Physics Laboratory, University of Washington, Seattle, Washington, USA.

Ultrasound in Medicine & Biology
|November 30, 2020
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adjusted Comparison of First-line Enfortumab Vedotin Plus Pembrolizumab Versus Platinum-based Chemotherapy ± Avelumab Maintenance for the Treatment of Locally Advanced/Metastatic Urothelial Carcinoma.

European urology oncology·2026
Same author

Summary of Research: Aflibercept 8 mg versus Faricimab Treat‑and‑Extend for Diabetic Macular Edema or Neovascular Age‑Related Macular Degeneration: A Bayesian Fixed‑Effect Network Meta‑analysis of Clinical Trials.

Ophthalmology and therapy·2026
Same author

A systematic comparison of cavitation regimes and histotripsy efficiency across pulse duration and repetition rate in a fibrous tissue mimicking phantom.

Research square·2026
Same author

Preclinical Assessment of an Image-Guided Histotripsy System for Renal Ablation.

IEEE transactions on bio-medical engineering·2026
Same author

Correction: Aflibercept 8 mg versus Faricimab Treat-and-Extend for Diabetic Macular Edema or Neovascular Age-Related Macular Degeneration: A Bayesian Fixed-Effect Network Meta-analysis of Clinical Trials.

Ophthalmology and therapy·2026
Same author

The first limb-sparing use of histotripsy for canine osteosarcoma.

Scientific reports·2026
Same journal

Acoustic Characterization of a Modified IEC Agar-Based Tissue-Mimicking Material Across the 3.5-50 MHz Frequency Range.

Ultrasound in medicine & biology·2026
Same journal

Deep Learning-Based Standard Section Recognition and Multi-Organ Segmentation in Upper Abdominal Ultrasound.

Ultrasound in medicine & biology·2026
Same journal

Cardiac Natural Mechanical Wave Detection and Speed Estimation Using Deep Learning-Based 2-D Ultrasound Imaging: A Feasibility Study.

Ultrasound in medicine & biology·2026
Same journal

Region-Specific Evaluation of Plaque Segmentation in Cross-sectional Projections of Carotid Ultrasound Images Using Deep Learning Models in a Sub-clinical Atherosclerosis Cohort.

Ultrasound in medicine & biology·2026
Same journal

Simulating the Dedifferentiation Process of Thyroid Cancer: Insights from Mouse Models and Ultrasound Imaging.

Ultrasound in medicine & biology·2026
Same journal

A Nomogram Based on Ultrasound Features for Predicting Major Intra-Operative Hemorrhage in Patients With Placenta Accreta Spectrum (PAS).

Ultrasound in medicine & biology·2026
See all related articles
This summary is machine-generated.

Focused ultrasound, specifically cavitation histotripsy, shows promise for non-invasively treating infected abscesses by mechanically damaging bacteria. This method may offer an alternative to antibiotics and catheter drainage.

Area of Science:

  • Biomedical Engineering
  • Medical Physics
  • Infectious Diseases

Background:

  • Infected abscesses are common complications requiring antibiotic and drainage treatments.
  • Antibiotic resistance is a growing challenge in treating bacterial infections.
  • Current treatments like catheter drainage and surgical washout have limitations.

Purpose of the Study:

  • To investigate focused ultrasound, specifically histotripsy, as a non-invasive treatment for infected abscesses.
  • To compare the efficacy of boiling histotripsy and cavitation histotripsy in reducing bacterial load.
  • To evaluate the safety and feasibility of histotripsy in a porcine abscess model.

Main Methods:

  • Subcutaneous and intramuscular abscesses were created in a porcine model.
Keywords:
AbscessAcoustic bactericideBacteria inactivationFocused UltrasoundFocused ultrasoundHigh-intensity focused ultrasoundHistotripsyImage-Guided Therapy

More Related Videos

Author Spotlight: A Reproducible and Efficient Method for Accessing Porcine Brain via Craniectomy
04:26

Author Spotlight: A Reproducible and Efficient Method for Accessing Porcine Brain via Craniectomy

Published on: July 5, 2024

718
A Porcine Model of Acute Autologous Pulmonary Embolism
07:44

A Porcine Model of Acute Autologous Pulmonary Embolism

Published on: September 6, 2024

662

Related Experiment Videos

Last Updated: Nov 28, 2025

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug
07:50

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug

Published on: June 4, 2021

3.0K
Author Spotlight: A Reproducible and Efficient Method for Accessing Porcine Brain via Craniectomy
04:26

Author Spotlight: A Reproducible and Efficient Method for Accessing Porcine Brain via Craniectomy

Published on: July 5, 2024

718
A Porcine Model of Acute Autologous Pulmonary Embolism
07:44

A Porcine Model of Acute Autologous Pulmonary Embolism

Published on: September 6, 2024

662
  • Ultrasound imaging monitored abscess maturity and post-treatment outcomes.
  • Bacterial colony counts and histopathological evaluations assessed treatment effectiveness and collateral damage.

    • Main Results:

    • Cavitation histotripsy significantly reduced bacterial load compared to boiling histotripsy.
    • Cavitation histotripsy utilized a smaller treatment volume.
    • Histotripsy demonstrated potential for in situ abscess treatment with minimal collateral damage.

    Conclusions:

    • Focused ultrasound, particularly cavitation histotripsy, presents a novel, non-invasive therapeutic approach for abscesses.
    • This technology may reduce reliance on antibiotics and long-term catheterization.
    • Further research is warranted to explore its clinical applicability for acoustically accessible abscesses.