Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Sex Differences in Scalp-to-Cortex Distance: Implications for Transcranial Magnetic Stimulation Efficacy in Alcohol Use Disorder.

Alcohol, clinical & experimental research·2026

Same author

Continuous theta burst stimulation to the frontal pole durably decreases medial frontoamygdala connectivity.

International review of psychiatry (Abingdon, England)·2026

Same author

Adapting a Regulation of Craving Magnetic Resonance Imaging Task to Generate Functional Repetitive Transcranial Magnetic Stimulation Targets for the Ventromedial and Dorsolateral Prefrontal Cortex in Treatment-Seeking Participants with Cannabis Use Disorder.

medRxiv : the preprint server for health sciences·2026

Same author

Concurrent taVNS-fMRI Revealed Similar Brain Activation Patterns Elicited by Stimulation of the Mastoid and the Cymba Conchae.

Neuromodulation : journal of the International Neuromodulation Society·2026

Same author

Illuminating posterior targets for TMS beyond the prefrontal cortex.

Nature. Mental health·2026

Same author

Neuromodulation approaches and applications in the management of post-stroke pain: a comprehensive review.

Frontiers in neurology·2026

Search research articles

Related Experiment Video

Updated: Nov 28, 2025

Electrode Positioning and Montage in Transcranial Direct Current Stimulation

Electrode Positioning and Montage in Transcranial Direct Current Stimulation

Published on: May 23, 2011

Non-invasive brain stimulation as a tool to decrease chronic pain in current opiate users: A parametric evaluation of

Julia P Imperatore¹, Daniel M McCalley¹, Jeffrey J Borckardt²

¹Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA.

Drug and Alcohol Dependence

|November 30, 2020

Summary

This summary is machine-generated.

Motor cortex transcranial magnetic stimulation (TMS) significantly reduced pain interference and opiate cravings more than dorsolateral prefrontal cortex TMS in chronic pain patients. This suggests motor cortex is a promising target for opiate dependence.

Keywords:

Neuromodulation Opiates Pain Transcranial magnetic stimulation

More Related Videos

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

$Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain$

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain

Published on: May 10, 2017

Related Experiment Videos

Last Updated: Nov 28, 2025

Electrode Positioning and Montage in Transcranial Direct Current Stimulation

Electrode Positioning and Montage in Transcranial Direct Current Stimulation

Published on: May 23, 2011

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

$Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain$

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain

Published on: May 10, 2017

Area of Science:

Neurology
Pain Management
Neuroscience

Background:

Chronic pain often leads to opiate use, presenting a community health crisis.
Transcranial magnetic stimulation (TMS) is an emerging non-invasive treatment for chronic pain.
Optimal TMS stimulation site for pain and opiate use remains unclear.

Purpose of the Study:

To directly compare the efficacy of dorsolateral prefrontal cortex (DLPFC) versus motor cortex (MC) TMS.
To assess the impact on pain severity and the urge to use opiates in chronic pain patients.

Main Methods:

Twenty-two chronic pain patients using prescription opiates were randomized.
Received 10 sessions of 10 Hz repetitive TMS (rTMS) to either left DLPFC or left MC.
Multivariate linear models analyzed pain, distress, and opiate urge using Brief Pain Inventory (BPI) data.

Main Results:

Twenty participants completed the study.
Motor cortex (MC) TMS significantly decreased pain interference compared to DLPFC TMS.
MC stimulation showed larger effects on pain interference (Cohen's d: 0.7) and opiate urge (Cohen's d: 0.5).

Conclusions:

Motor cortex (MC) stimulation appears more effective than DLPFC stimulation.
MC TMS may be a promising target for reducing opiate dependence.
Further research into MC TMS for chronic pain and opiate use is warranted.