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An In Vitro Model for Studying Tau Aggregation Using Lentiviral-mediated Transduction of Human Neurons
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Soluble 4R0N Tau Abrogates Endocytic Vesicular Dynamics

Tharun Selvam Mahendran1, S N Suresh2, Lakshmi Garimella1

  • 1Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India.

Frontiers in Aging Neuroscience
|November 30, 2020
PubMed
Summary

Soluble tau disrupts endolysosomal and autophagic pathways, impacting amyloid precursor protein (APP) trafficking. This suggests a novel mechanism by which soluble tau may contribute to Alzheimer's disease pathogenesis.

Keywords:
Alzheimer’s diseaseamyloid precursor protein (APP)autophagic stressendocytic dysfunctionendosome dysfunctionsoluble 4R0N tauvesicle trackingvesicular trafficking

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