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[Activated oncogenes in human tumors]
T Noguchi1, J Adelaide, I Marics
1Unité 119 de l'INSERM, Marseille, France.
Bulletin Du Cancer
|January 1, 1987
Abstract:
ras oncogenes are cellular genes altered by point mutation in 10 to 30% of human tumors. Under this mutated form they play a role in the malignant process, probably in association with other oncogenes. The different ras genes identified in human cancers, the point mutations that activate the ras genes and the properties of the ras proteins are described.
Insights
Ras oncogenes, altered by point mutation in human cancers, contribute to malignancy, likely with other oncogenes. This review details ras genes, activating mutations, and protein properties in cancer.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Context:
- Ras oncogenes are frequently mutated in human cancers.
- These mutations are crucial for malignant transformation.
- Ras proteins are key regulators of cellular processes.
Purpose:
- To describe the ras genes implicated in human cancers.
- To detail the specific point mutations that activate ras genes.
- To outline the functional properties of activated ras proteins.
Summary:
- Ras oncogenes are cellular genes that undergo point mutations in 10-30% of human tumors.
- Mutated ras oncogenes play a significant role in cancer development, potentially interacting with other oncogenes.
- The review covers identified ras genes in human cancers, the activating point mutations, and the characteristics of the resulting ras proteins.
Impact:
- Provides a comprehensive overview of ras oncogenes in cancer.
- Highlights the molecular mechanisms underlying ras-driven tumorigenesis.
- Serves as a foundational resource for researchers studying ras in oncology.