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Longitudinal Changes on Clinical Features in 28 Children With COVID-19 in Shenzhen, China

Xuejiao Liao1, Jiaye Liu1, Ziyi He1

  • 1The Third People's Hospital of Shenzhen, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, China.

Frontiers in Medicine
|November 30, 2020
PubMed

Insights

Coronavirus disease 2019 (COVID-19) in children is typically mild, but viral shedding can persist after hospital discharge. Public health strategies must consider pediatric infectiousness for effective control measures.

Area of Science:

  • Pediatric Infectious Diseases
  • Viral Respiratory Illnesses

Background:

  • Coronavirus disease 2019 (COVID-19) emerged globally in late 2019.
  • Understanding pediatric COVID-19 clinical characteristics and viral shedding is crucial for public health.

Purpose of the Study:

  • To investigate the clinical features of COVID-19 in children.
  • To determine the duration of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) viral shedding in pediatric patients post-discharge.

Main Methods:

  • Retrospective data retrieval from 28 pediatric COVID-19 patients.
  • Analysis of SARS-CoV-2 viral load and antibody dynamics during and after hospitalization.
  • Follow-up for at least one month post-discharge.

Main Results:

  • COVID-19 presented mildly in all pediatric patients.
  • None of the children progressed to severe disease.
  • Viral shedding of SARS-CoV-2 was detected in 10 patients at 1 month and 4 patients at 2 months post-discharge.
  • Immunoglobulin-M (IgM) levels were inconsistently detectable in a small subset of children.

Conclusions:

  • COVID-19 is generally mild in the pediatric population.
  • Persistent viral shedding necessitates adapted public health control measures targeting children.
  • Further research into pediatric SARS-CoV-2 dynamics and immunity is warranted.

Keywords:
antibodyclinical featurescoronavirus disease 2019 (COVID-19)pediatricsevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

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