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Updated: Nov 28, 2025
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Enhanced Sample Multiplexing of Tissues Using Combined Precursor Isotopic Labeling and Isobaric Tagging cPILOT
Published on: May 1, 2017
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Traces pilot pharmacokinetic study dataset
S Gilliot1, A S Ducloy-Bouthors1,2, B Hennart3
1Univ. Lille, ULR 7365 - GRITA - Groupe de Recherche sur les formes Injectables et les Technologies Associées, F-59000 Lille, France.
Data in Brief
|November 30, 2020
Summary
This study analyzed tranexamic acid pharmacokinetics in patients with hemorrhagic Cesarean sections. Patient characteristics like weight and height significantly impacted drug distribution, informing future dosing strategies.
Area of Science:
- Pharmacology
- Clinical Pharmacy
- Obstetrics
Background:
- Hemorrhagic Cesarean sections pose significant risks.
- Tranexamic acid is used to reduce blood loss.
- Understanding its pharmacokinetics is crucial for effective treatment.
Purpose of the Study:
- To analyze the pharmacokinetics of tranexamic acid in patients undergoing hemorrhagic Cesarean sections.
- To identify patient-specific factors influencing tranexamic acid distribution.
- To inform optimized dosing regimens.
Main Methods:
- Collected pharmacokinetic data (blood and urine concentrations) from nine patients receiving intravenous tranexamic acid.
- Developed a pharmacokinetic compartment model to estimate individual parameters.
- Correlated patient anthropometric and clinical data with pharmacokinetic parameters.
Main Results:
- Tranexamic acid dose, patient height, body weight, and ideal body weight were identified as significant factors affecting its volume of distribution.
- These covariates were further explored using multi-regression analysis.
Conclusions:
- Patient characteristics significantly influence tranexamic acid pharmacokinetics.
- Individualized dosing based on covariates like weight and height may improve treatment efficacy.
- Further research can refine tranexamic acid administration in obstetric hemorrhage.
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