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Marie-Charlotte Brüggen1,2,3, Georg Stingl4

  • 1Medizinische Fakultät, University of Zurich, Zürich, Schweiz.

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|November 30, 2020
PubMed
Summary
This summary is machine-generated.

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Subcutaneous white adipose tissue (SWAT), a skin layer, harbors immune cells like macrophages and T-lymphocytes. These cells suggest SWAT has an immune protective function, potentially mitigating inflammatory responses.

Area of Science:

  • Dermatology
  • Immunology
  • Adipose Tissue Biology

Context:

  • The skin's outer boundary comprises the epidermis, dermis, and subcutaneous white adipose tissue (SWAT).
  • While the epidermis and dermis are recognized as immune barriers, SWAT's role remains less understood.
  • SWAT consists of lobules of adipocytes separated by vascularized connective tissue septa.

Purpose:

  • To investigate the immunological characteristics of human subcutaneous white adipose tissue (SWAT).
  • To identify and characterize the immune cells present within healthy SWAT.
  • To elucidate the potential immune functions of SWAT within the skin.

Summary:

  • Immunophenotypic analysis of SWAT revealed the presence of immune cells, primarily macrophages and T-lymphocytes.

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  • These immune cells exhibit phenotypes suggesting anti-inflammatory and regulatory roles.
  • Healthy SWAT shows no signs of inflammation but actively contains these immune cells.

    • Impact:

    • SWAT possesses a mechanical protective function.
    • SWAT may also contribute an immunological protective role, modulating immune and inflammatory reactions.
    • This finding expands the understanding of skin's complex defense mechanisms beyond the epidermis and dermis.