Microbial interactions and immunity response in oral Candida species

Area of Science:

• Immunology
• Microbiology
• Infectious Diseases

Background:

• Oral candidiasis is a common noncommunicable disease linked to severe local and systemic conditions.
• Immunosuppressed individuals (e.g., HIV, cancer patients, those on long-term antibiotics) are more susceptible to recurrent oral candidiasis.
• While Candida albicans is the predominant species, non-albicans Candida species are increasingly implicated.

Purpose of the Study:

• To review and analyze common interactions between oral Candida species and bacteria, as well as Candida-Candida interactions.
• To examine the host immune response in the context of oral candidiasis.
• To identify key factors for successful treatment and novel therapeutic strategies.

Main Methods:

• Literature search conducted in PubMed and Web of Science (WoS).
• Analysis of existing studies on oral Candida spp. interactions and host immunity.
• Review focused on common interactions and immune responses in oral candidiasis.

Main Results:

• Oral candidiasis involves complex interactions between Candida species and other microbes.
• Host immune responses play a critical role in managing oral Candida infections.
• Emerging non-albicans Candida species present unique challenges in treatment and understanding.

Conclusions:

• A comprehensive understanding of oral Candida spp. interactions and host immunity is essential for effective treatment.
• Further research into these interactions can guide the development of novel therapeutic approaches.
• Addressing the rise of non-albicans Candida species requires updated knowledge of their pathogenicity and host interactions.