Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pancreatic B-cell function during normal pregnancy.

E Nordlander1, U Hanson, B Persson

  • 1Department of Obstetrics and Gynecology, Karolinska Hospital, Stockholm, Sweden.

Diabetes Research (Edinburgh, Scotland)
|November 1, 1987
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Decreased glomerular filtration rate in solderers exposed to cadmium.

Occupational and environmental medicine·1995
Same author

Scalp blood lactate: a new test strip method for monitoring fetal wellbeing in labour.

British journal of obstetrics and gynaecology·1995
Same author

Enzymuria in a population living near a cadmium battery plant.

Occupational and environmental medicine·1995
Same author

Influence of body temperature on thyrotropic hormone release and lipolysis in the newborn infant.

Acta paediatrica (Oslo, Norway : 1992)·1995
Same author

Radioimmunoassays for glutamic acid decarboxylase (GAD65) and GAD65 autoantibodies using 35S or 3H recombinant human ligands.

Journal of immunological methods·1995
Same author

Cancer incidence and mortality of patients with suspected solvent-related disorders.

Scandinavian journal of work, environment & health·1995

Urinary C-peptide excretion significantly increased during pregnancy, even by 12 weeks, suggesting early insulin resistance. This biomarker change was not linked to weight gain but correlated with postpartum body weight.

Area of Science:

  • Endocrinology
  • Metabolic Health
  • Pregnancy Physiology

Background:

  • Gestational diabetes mellitus (GDM) is a growing concern, characterized by insulin resistance during pregnancy.
  • Understanding early physiological changes in insulin secretion during normal gestation is crucial for identifying at-risk individuals.
  • C-peptide, a marker of insulin production, can provide insights into pancreatic beta-cell function.

Purpose of the Study:

  • To investigate the changes in 24-hour urinary C-peptide excretion throughout normal pregnancy.
  • To determine the relationship between urinary C-peptide excretion and maternal anthropometric measures (weight, skinfold thickness) and glucose tolerance.
  • To assess if early gestational increases in urinary C-peptide suggest pre-existing insulin resistance.

Main Methods:

Related Experiment Videos

  • Studied 19 healthy, normal-weight pregnant women with normal glucose tolerance.
  • Collected 24-hour urine samples at 12, 20, 30, 36 weeks of gestation and 6-8 weeks postpartum.
  • Measured urinary C-peptide excretion (total and per kg body weight) and correlated findings with weight gain, skinfold thickness, and oral glucose load tests.

Main Results:

  • Urinary C-peptide excretion showed a significant, progressive increase with advancing gestation, being 4 times higher by 12 weeks compared to non-pregnant levels.
  • No significant relationship was found between urinary C-peptide excretion and maternal weight, weight gain, or skinfold thickness during pregnancy.
  • A significant positive correlation was observed between postpartum urinary C-peptide excretion and postpartum body weight (r = 0.54, p < 0.05).

Conclusions:

  • Urinary C-peptide excretion increases substantially early in normal pregnancy, independent of maternal weight or adiposity.
  • The early rise in urinary C-peptide suggests that insulin resistance may be present from the first trimester of normal gestation.
  • These findings highlight the dynamic changes in insulin secretion during pregnancy and the potential utility of urinary C-peptide as an early indicator.