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Efficacy, safety, and predictability of transepithelial photorefractive keratectomy: meta-analysis
Alexandra Sabau1, Loay Daas, Abdelshafi Behkit
1From the Department of Ophthalmology, Saarland University Medical Center, Homburg/Saar, Germany (Sabau, Daas, Flockerzi, Seitz); Medical Biometrics, Epidemiology and Health Informatics Institute, Homburg/Saar, Germany (Behkit, Wagenpfeil); Institute of Experimental Ophthalmology, Saarland University, Homburg/Saar, Germany (Langenbucher); Department of Ophthalmology, Medical University of Graz, Graz, Austria (Ardjomand).
Purpose:
To evaluate the efficacy, safety, and predictability of transepithelial photorefractive keratectomy (TransPRK) for correcting myopia, astigmatism, and hyperopia.
Setting:
Department of Ophthalmology, Saarland University Medical Center, Homburg/Saar, Germany.
Design:
Meta-analysis of retrospective or prospective studies.
Methods:
Relevant studies were collected from Medline and included when meeting the following predefined criteria: randomized controlled trials, at least 1 of the main outcome measures as efficacy, safety, or predictability, and 1 common TransPRK laser (Schwind Amaris). The parameters estimates and 95% CI were derived from random-effects meta-analysis to account for possible heterogeneity.
Results:
Because hyperopia studies did not meet the inclusion criteria, the results are centered on myopia and astigmatism. Sixteen studies with a total of 1924 treated eyes were included in the meta-analysis. The mean efficacy, safety, and predictability had a probability of 94% (CI, 0.86-0.97), 0% (CI, 0.00-0.03), and 89% (CI, 0.82-0.93), respectively. The mean correction index, difference vector, and index of success had a value of 1.01 (CI, 1.01-1.02), 0.20 (CI, 0.06-0.34), and 0.12 (CI, 0.07-0.18), respectively.
Conclusions:
This summary estimate showed that TransPRK was highly effective, safe, and predictable in correcting myopia and/or astigmatism.
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