Top 10 priorities for future infertility research: an international consensus development study†  ‡

Area of Science:

• Reproductive Medicine and Endocrinology
• Public Health and Healthcare Policy

Background:

• Numerous unanswered questions in infertility prevention, management, and consequences hinder improved patient care.
• A significant gap exists in understanding and addressing the multifaceted aspects of fertility challenges.

Purpose of the Study:

• To identify and prioritize future research needs in the field of infertility.
• To establish a consensus-driven agenda for research in male infertility, female/unexplained infertility, medically assisted reproduction, and ethics/access to care.

Main Methods:

• A multi-stage process involving international surveys, systematic reviews of guidelines, and consensus development meetings.
• Utilized the modified nominal group technique with diverse stakeholders, including patients, healthcare professionals, and funders.
• Data collated from 388 participants (initial survey) and 317 respondents (interim survey), culminating in a consensus meeting of 41 international participants.

Main Results:

• Identified the top 10 research priorities across four key areas: male infertility, female and unexplained infertility, medically assisted reproduction, and ethics/access to care.
• Priorities encompass prevention, treatment, and the longer-term impact of infertility, including psychological aspects and access in low-resource settings.
• Highlighted the need for diverse research methodologies, from laboratory science to qualitative and quantitative population studies.

Conclusions:

• The identified research priorities represent critical clinical needs as perceived by a broad range of stakeholders.
• This consensus-driven agenda is expected to guide research funding organizations and researchers in shaping future infertility research.
• Addressing these priorities will advance the field and improve care for individuals experiencing fertility problems.