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The Vascular Component of Melasma: A Systematic Review of Laboratory, Diagnostic, and Therapeutic Evidence

Natasha Masub1,2, Julie K Nguyen1,2, Evan Austin1,2

  • 1Department of Dermatology, State University of New York, Downstate Health Sciences University, Brooklyn, New York.

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [Et Al.]
|November 30, 2020
PubMed
Abstract

Insights

Antivascular agents show promise for treating melasma, a hyperpigmentation disorder. Tranexamic acid and laser therapies targeting vascular abnormalities are effective, but more research is needed.

Area of Science:

  • Dermatology
  • Hyperpigmentation Disorders
  • Vascular Biology

Background:

  • Melasma is a common acquired hyperpigmentation disorder.
  • Symmetric brown patches on the face are characteristic of melasma.
  • Vascular abnormalities are implicated in melasma pathogenesis.

Purpose of the Study:

  • Evaluate evidence on antivascular agents for melasma treatment.
  • Assess the safety and efficacy of these therapies.
  • Provide clinical recommendations based on current research.

Main Methods:

  • Systematic review of PubMed, EMBASE, and Cochrane databases.
  • Included original research on vascularity and antivascular therapeutics in melasma.
  • Followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.

Main Results:

  • Identified 34 original research articles.
  • Included 4 laboratory, 15 diagnostic, and 15 therapeutic studies.
  • Found promising evidence for tranexamic acid and laser/light therapies.

Conclusions:

  • Tranexamic acid and laser therapies show potential for treating melasma's vascular component.
  • More rigorous clinical trials are needed to confirm efficacy.
  • Antivascular agents may be considered for melasma treatment; further research is warranted.

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