Hypoxia and its preconditioning on cardiac and vascular remodelling in experimental animals

Since oxygen (O₂) is indispensable for mammalian life, every cell in the body is endowed with mechanisms to detect and to respond to changes in the O₂ levels in the microenvironment. The heart and the brain are the two most vital, life-supporting organs requiring a continuous supply of O₂ to sustain their high metabolic rate. On being challenged with hypoxia, maintenance of O₂ supply to these organs even at the cost of others becomes a priority. This review describes the cardiovascular, skeletal muscle vascular, pulmonary vascular and cerebrovascular remodelling in face of chronic mild hypoxia exposure and the underlying mechanisms, with special reference to the role of oxidative stress, hypoxia signalling, autonomic nervous mechanisms. The significance of the normalized wall index (NWI) in assessing the remodelling of the vessels particularly of the intramyocardial coronary artery has been underscored. The review also highlights the basic concepts of hypoxic preconditioning and the subsequent protection of the brain against an acute ischemic insult in preclinical studies hinting towards its possible therapeutic potential in the management of ischemic stroke.