Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

299
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
299
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

334
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
334
Vaccinations01:51

Vaccinations

49.6K
Overview
49.6K
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

560
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
560
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

972
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
972
Cross-reactivity00:42

Cross-reactivity

32.2K
Overview
32.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of antibodies in vaccine-mediated protection against tuberculosis.

Cellular & molecular immunology·2022
Same author

Editorial: Advances in Immunotherapeutic Approaches to Tuberculosis.

Frontiers in immunology·2021
Same author

Mucosal Therapy of Multi-Drug Resistant Tuberculosis With IgA and Interferon-γ.

Frontiers in immunology·2020
Same author

Selection of a Single Domain Antibody, Specific for an HLA-Bound Epitope of the Mycobacterial Ag85B Antigen.

Frontiers in immunology·2020
Same author

Vaccine development might be handled more effectively in biotech companies than in academia.

BMJ (Clinical research ed.)·2018
Same author

Significance of antigen and epitope specificity in tuberculosis.

Frontiers in immunology·2014

Related Experiment Video

Updated: Nov 28, 2025

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
06:32

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

Published on: September 19, 2016

10.9K

Tuberculosis vaccination needs to avoid 'decoy' immune reactions.

Juraj Ivanyi1

  • 1Centre for Host-Microbiome Interactions, Guy's Campus of Kings College London, SE1, 1UL, United kingdom.

Tuberculosis (Edinburgh, Scotland)
|November 30, 2020
PubMed
Summary

New tuberculosis vaccines face challenges as Bacillus Calmette-Guerin (BCG) priming may hinder protection. Pathogenic bacteria may use

Keywords:
ImmunologyPathogenesisTuberculosisVaccination

More Related Videos

Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis
06:26

Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis

Published on: July 28, 2023

2.7K
Enrichment of Native and Recombinant Extracellular Vesicles of Mycobacteria
06:38

Enrichment of Native and Recombinant Extracellular Vesicles of Mycobacteria

Published on: December 8, 2023

1.3K

Related Experiment Videos

Last Updated: Nov 28, 2025

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
06:32

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

Published on: September 19, 2016

10.9K
Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis
06:26

Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis

Published on: July 28, 2023

2.7K
Enrichment of Native and Recombinant Extracellular Vesicles of Mycobacteria
06:38

Enrichment of Native and Recombinant Extracellular Vesicles of Mycobacteria

Published on: December 8, 2023

1.3K

Area of Science:

  • Immunology
  • Vaccinology
  • Microbiology

Background:

  • Current tuberculosis vaccine development focuses on antigens, vectors, and adjuvants.
  • Bacillus Calmette-Guerin (BCG) is commonly used for priming in vaccine efficacy studies.
  • BCG, despite attenuation, may elicit unfavorable immune responses for active disease protection.

Purpose of the Study:

  • To highlight potential detrimental immune mechanisms induced by BCG priming.
  • To propose that bacterial 'decoy' mechanisms contribute to tuberculosis pathogenesis and transmission.

Main Methods:

  • This article presents a theoretical postulation based on existing knowledge of tuberculosis immunology.
  • It analyzes the evolutionary strategies of pathogenic tubercle bacilli.
  • It discusses the implications for current vaccine development approaches.

Main Results:

  • BCG priming might activate immune responses that paradoxically promote disease progression.
  • Pathogenic bacteria may possess 'decoy' components that evade host resistance.
  • These decoys can stimulate cytokine profiles leading to granuloma reactivation and infectious cavities.

Conclusions:

  • BCG's immune stimulation may not be universally beneficial for tuberculosis prevention.
  • Bacterial decoy mechanisms are implicated in disease transition and transmission.
  • Future vaccine design should consider avoiding these detrimental immune responses for enhanced efficacy.