Related Experiment Video

Updated: Nov 28, 2025

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
08:40

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library

Published on: April 6, 2012

17.9K

miR-26 family and its target genes in tumorigenesis and development

Chuangang Li1, Yongyi Li2, Yufeng Lu3

  • 1The Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China.

Critical Reviews in Oncology/Hematology
|November 30, 2020
PubMed

Insights

The microRNA-26 family, including miR-26a and miR-26b, is linked to cancer development. These microRNAs (miRNAs) may serve as valuable biomarkers and therapeutic targets for various tumors.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • The microRNA-26 family (miR-26a, miR-26b, miR-1297, miR-4465) consists of conserved small RNAs with identical seed regions.
  • Hypoxia induces miR-26 expression via a HIF-dependent pathway, and it is upregulated during cell differentiation.

Purpose of the Study:

  • To review the role of the miR-26 family and its target genes in tumorigenesis and cancer development.
  • To summarize the potential of miR-26 as a biomarker and therapeutic target in oncology.

Main Methods:

  • Literature review of studies on miR-26 family expression and function in cancer.
  • Analysis of validated miR-26 target genes and their involvement in cancer-related processes.

Main Results:

  • miR-26 family members are detected in various tumors.
  • Validated miR-26 targets are implicated in cell metabolism, proliferation, differentiation, apoptosis, invasion, and metastasis.

Conclusions:

  • miR-26 expression is dysregulated in cancer and influences key oncogenic pathways.
  • The miR-26 family holds promise as a diagnostic biomarker and a novel therapeutic strategy for cancer treatment.
Keywords:
Expression and regulationTarget genesTumorsmiR-26 family

More Related Videos

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells09:45

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells

Published on: May 21, 2019

8.7K
Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

7.8K

Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.2K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.5K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
23.3K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.9K
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.4K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.4K