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Predicted Reference Equations for Spirometry Indices as a Proxy from Anthropometry Measurements of Nigerian Children
Olufemi S Akodui1, Abiodun O Faleti2, Folashade A Adekanmbi1
1Department of Paediatrics, Olabisi Onabanjo University Teaching Hospital, Sagamu, Ogun, Nigeria.
Insights
Arm span measurements can serve as a reliable proxy for spirometry indices in children with sickle cell anemia, aiding respiratory care when spirometers are unavailable.
Area of Science:
- Pediatric Pulmonology
- Hematology
- Clinical Biomechanics
Background:
- Lung complications significantly contribute to morbidity and mortality in sickle cell disease patients.
- Effective respiratory care for children with sickle cell anemia necessitates local predicted spirometry values.
Purpose of the Study:
- To establish reference equations for estimating spirometry indices in Nigerian children with sickle cell anemia.
- To provide accessible spirometry proxies for use when spirometers are not readily available.
Main Methods:
- A cross-sectional study was conducted on Nigerian children aged 5-12 years with sickle cell anemia.
- Linear regression models were developed to estimate reference values for spirometric indices.
- Arm span and age were evaluated as independent variables for prediction.
Main Results:
- Arm span demonstrated the highest coefficient of determination (R2) and lowest standard error for predicting peak expiratory flow rate (PEFR).
- Prediction models for PEFR and forced expiratory volume in 1 second (FEV1) showed minimal mean estimate differences from actual values.
- Prediction models for forced vital capacity (FVC) showed a non-significant increase in mean estimates.
Conclusions:
- Arm span is a preferred proxy for spirometry indices in children with sickle cell anemia.
- This finding supports improved respiratory assessment in resource-limited settings.
Background:
Significant morbidity and mortality in patients with sickle cell disease are accounted for by lung complications. To facilitate good respiratory care for children with sickle cell anaemia the generation of local predicted values is highly important.
Objective:
To determine the reference equations for spirometry indices estimation in children with sickle cell anaemia, which can be readily used as proxy when there is no easy accessibility to spirometer.
Methods:
A cross-sectional study with linear regression models developed to estimate reference values for spirometric indices in Nigerian children with sickle cell anaemia aged 5-12 years.
Results:
Age as independent variables for estimation of forced expiratory volume in 1 s (FEV1) was associated with lowest coefficient of determination (R2) and highest standard error. The coefficient of determination (R2) and standard error was highest and lowest, respectively, when arm span was used to determine peak expiratory flow rate (PEFR). Prediction models for PEFR and FEV1 gave the closest mean estimates that were 0.18 and 0.16 lower and higher than the actual mean PEFR and FEV1, respectively, but the differences was significant only in FEV1. On the contrary the prediction models for forced vital capacity (FVC) gave mean estimates that was 1.02 higher than the actual mean FVC, however, the finding was not significant.
Conclusion:
Preferred proxy for spirometry indices in children with sickle cell anaemia may be arm span.
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