[Anemia and iron deficiency - treatment options in chronic kidney disease and in chronic heart failure]

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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

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Insa E Emrich1, Michael Böhm1, Gunnar H Heine2,3

  • 1Klinik für Innere Medizin III, Klinik für Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Homburg.

Deutsche Medizinische Wochenschrift (1946)
|November 30, 2020
PubMed

Insights

Anemia is common in chronic kidney disease and heart failure. While some treatments lack benefits, intravenous iron shows promise in dialysis patients, and new HIF stabilizers are being studied for chronic kidney disease.

Area of Science:

  • Nephrology
  • Cardiology
  • Hematology

Background:

  • Anemia and iron deficiency are prevalent in chronic kidney disease (CKD) and chronic heart failure (CHF).
  • These conditions can predict future renal and cardiovascular events.
  • Current anemia treatments like erythropoietin have not shown prognostic benefits in CKD or CHF.

Purpose of the Study:

  • To review the current understanding of anemia and iron deficiency in CKD and CHF.
  • To evaluate the prognostic implications and treatment benefits of iron supplementation and novel therapies.

Main Methods:

  • Literature review and analysis of clinical trial data.
  • Examination of epidemiological associations between anemia, iron deficiency, and adverse outcomes.
  • Assessment of treatment efficacy for anemia in CKD and CHF.

Main Results:

  • Intravenous iron supplementation demonstrated a prognostic benefit in a subgroup of chronic dialysis patients.
  • Ongoing trials are investigating the prognostic impact of intravenous iron in CHF.
  • HIF stabilizers represent a new therapeutic option for anemia in CKD, with ongoing safety studies.

Conclusions:

  • Standard anemia treatments have not improved prognosis in CKD or CHF.
  • Intravenous iron shows potential benefits, particularly in dialysis patients.
  • HIF stabilizers offer a novel approach for CKD anemia, but their efficacy and safety in CHF remain undetermined.

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