Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

231
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
231
Autoimmune Disorders01:29

Autoimmune Disorders

1.2K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
1.2K
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

261
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
261
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

15.0K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
15.0K
Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

136
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
136
T Cell Types and Functions01:24

T Cell Types and Functions

1.8K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Innere Medizin (Heidelberg, Germany)·2026
Same author

[Infection and rheumatic diseases].

Zeitschrift fur Rheumatologie·2025
Same author

[Storage diseases].

Deutsche medizinische Wochenschrift (1946)·2024
Same author

Looking back on 51 years of the Carol Nachman Prize in Rheumatology-significance for the field of spondyloarthritis research.

Zeitschrift fur Rheumatologie·2024
Same author

HLA-B27 and the role of specific T cell receptors in the pathogenesis of spondyloarthritis.

Annals of the rheumatic diseases·2024
Same author

[Vasculitis].

Innere Medizin (Heidelberg, Germany)·2024

Related Experiment Video

Updated: Nov 28, 2025

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

595

[Reactive arthritis - a disease almost forgotten?]

Elisabeth Märker-Hermann1

  • 1Klinik Innere Medizin IV (Rheumatologie, Klinische Immunologie und Nephrologie), Helios Dr. Horst Schmidt Kliniken Wiesbaden.

Deutsche Medizinische Wochenschrift (1946)
|November 30, 2020
PubMed
Summary

Reactive arthritis (ReA) is an immune-mediated condition following infections, classified under spondyloarthropathies. Treatment focuses on anti-inflammatory drugs and immunosuppressants, not antibiotics.

More Related Videos

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

729
Author Spotlight: Implementation of BIVA for Analyzing Disease Risk Factors in Patients with Low Body Cell Mass
07:44

Author Spotlight: Implementation of BIVA for Analyzing Disease Risk Factors in Patients with Low Body Cell Mass

Published on: July 14, 2023

1.5K

Related Experiment Videos

Last Updated: Nov 28, 2025

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

595
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

729
Author Spotlight: Implementation of BIVA for Analyzing Disease Risk Factors in Patients with Low Body Cell Mass
07:44

Author Spotlight: Implementation of BIVA for Analyzing Disease Risk Factors in Patients with Low Body Cell Mass

Published on: July 14, 2023

1.5K

Area of Science:

  • Rheumatology
  • Immunology
  • Infectious Diseases

Background:

  • Reactive arthritis (ReA) is an aseptic, immune-mediated arthritis.
  • It typically follows urogenital, gastrointestinal, or respiratory tract infections.
  • ReA is classified within the spondyloarthritis group.

Purpose of the Study:

  • To define Reactive Arthritis (ReA).
  • To outline its classification, pathogenesis, and treatment.
  • To highlight the limited recent publications.

Main Methods:

  • Review of existing literature on Reactive Arthritis.
  • Classification based on clinical manifestations and preceding infections.
  • Discussion of pathogenetic factors including genetics (HLA-B27).

Main Results:

  • Triggering microorganisms are not typically found in affected joints.
  • Bacterial, immunological, and genetic factors (HLA-B27) are key in ReA pathogenesis.
  • Post-streptococcal, Lyme, and viral arthritis are excluded from ReA classification.

Conclusions:

  • Antibiotics are not indicated for ReA treatment.
  • Acute ReA is managed with NSAIDs.
  • Refractory ReA requires steroids, sulfasalazine, or TNF inhibitors.